Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

Project: Research

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The microneedle-based skin patch system allows the minimally invasive extraction of skin interstitial fluid, which offers hopes to realize the quantitative and non-invasive diagnosis/monitoring of biological/physiological signals (biomarkers) in the body. However, diagnosis with exiting microneedle devices suffer from the interferences of the complex physiological processes, thousands of different macromolecules and cells within skin tissue. They cannot realize the real-time conversion of biological/physiological signals to electronic signals either. To address this unmet need, this project is to develop a new generation of microneedle system that permits the interference-free, real-time, and quantitative detection of biological/physiological signals. Specifically, this platform is based on the development of self-filtering hydrogels (City University of Hong Kong) and the enzymatic electrodes (Tsinghua University), which are responsible for minimizing the interference and allowing the real-time conversion of biological signals to electronic signals, respectively. Two components will then be organically integrated into the microneedle skin patch using the microfabrication technology. Power supply and wireless transmitter components will finally be integrated into the same device. The function of this device will be evaluated in the mouse models by taking glucose, uric acid, and alcohol as the model biomarkers. 


Project number9054032
Grant typeNSFC
Effective start/end date1/01/21 → …