Key Genetic Alterations in Early-stage Pancreatobiliary Cancers
DescriptionPancreatobiliary carcinomas are among the most lethal malignancies, with an overall 5-year survival rate of about 5%. Thus, one important strategy for the management of pancreatobiliary cancer is early detection in high-risk populations, to reduce mortality of pancreatobiliary carcinomas. However, early-stage pancreatobiliary carcinomas is usually asymptomatic or Jack of specific symptoms, and early diagnosis is complicated by the coexistence of inflammation.We aimed to address these issues first in a clinical setting and, in the long term, a population setting. We will analyze, in Chinese population, the co-occurrence of KRAS/GNAS and key tumor suppressor genes in pancreatobiliary cancers in stages I and II of pancreatobiliary cancers. Based on a nested case-control design within one prospective cohort study, we will evaluate the feasibility of the above-described pancreatobiliary cancers-specific gene panel in a real-world, population-based setting, as the basis for the long term goal of detecting early- stage pancreatobiliary cancers.
|Effective start/end date||1/09/18 → …|