Key Genetic Alterations in Early-stage Pancreatobiliary Cancers

Project: Research

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Pancreatobiliary carcinomas are among the most lethal malignancies, with an overall 5-year survival rate of about 5%. Thus, one important strategy for the management of pancreatobiliary cancer is early detection in high-risk populations, to reduce mortality of pancreatobiliary carcinomas. However, early-stage pancreatobiliary carcinomas is usually asymptomatic or Jack of specific symptoms, and early diagnosis is complicated by the coexistence of inflammation.We aimed to address these issues first in a clinical setting and, in the long term, a population setting. We will analyze, in Chinese population, the co-occurrence of KRAS/GNAS and key tumor suppressor genes in pancreatobiliary cancers in stages I and II of pancreatobiliary cancers. Based on a nested case-control design within one prospective cohort study, we will evaluate the feasibility of the above-described pancreatobiliary cancers-specific gene panel in a real-world, population-based setting, as the basis for the long term goal of detecting early- stage pancreatobiliary cancers.


Project number7005111
Grant typeSRG-Fd
Effective start/end date1/09/18 → …