Identification of Circulating Biomarkers for Pancreatobiliary Cancers
DescriptionPancreatic ductal adenocarcinoma (PDAC) and biliary tumors have poor prognoses. Cell-free nucleic acids (ctNA) shed from pancreatobiliary tumors into the circulation via necrosis or secretion provide a window to detect early tumors and therefore would allow for timely intervention before it is too late. However, the half-life of ctNA is estimated to be about 2 hours in circulation. This transient nature of ctDNA could represent both advantage and disadvantage. We hypothesize that ctNA dynamics, i.e. intra-individual change of genetic alterations that are important in pancreatobiliary tumors, could be used to predict the growth of pre-clinical pancreatobiliary tumors and allows for their detection at pre-clinical and early stage. We will test our hypothesis using a population cohort where a subset of individuals whose serial plasma samples had been banked.
|Effective start/end date||1/09/17 → …|