Identification of Circulating Biomarkers for Pancreatobiliary Cancers

Project: Research

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Description

Pancreatic ductal adenocarcinoma (PDAC) and biliary tumors have poor prognoses. Cell-free nucleic acids (ctNA) shed from pancreatobiliary tumors into the circulation via necrosis or secretion provide a window to detect early tumors and therefore would allow for timely intervention before it is too late. However, the half-life of ctNA is estimated to be about 2 hours in circulation. This transient nature of ctDNA could represent both advantage and disadvantage. We hypothesize that ctNA dynamics, i.e. intra-individual change of genetic alterations that are important in pancreatobiliary tumors, could be used to predict the growth of pre-clinical pancreatobiliary tumors and allows for their detection at pre-clinical and early stage. We will test our hypothesis using a population cohort where a subset of individuals whose serial plasma samples had been banked.

Detail(s)

Project number7004815
Grant typeSRG-Fd
StatusActive
Effective start/end date1/09/17 → …