Functional Magnetic Resonance Imaging of the Adult Central Auditory System Following Long-Term and Passive Acoustic Exposure at Moderate Intensity

Project: Research

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High intensity acoustic exposures affect the central auditory system, which processes acoustic information. Such exposures can increase the minimum detectible intensity threshold. The impact of moderate intensity exposures that do not permanently increase threshold requires further study. Changes have recently been observed in brain cortical function following longterm and passive acoustic exposure at moderate intensity. However, studying subcortical functional changes and performing follow-up studies that assess recovery are also important. Functional magnetic resonance imaging (fMRI) is well suited to both needs. This project will establish fMRI to study changes in the adult auditory system following long-term and passive exposure at moderate intensity. Moderate intensity exposures can contribute to health deficits such as difficulties interpreting speech, sleep loss, and cardiovascular disease. Understanding the impact of such exposures on the central auditory system will improve the prevention, management, and treatment of auditory disorders. Studying the subcortex and performing follow-up studies are important to understanding the impact. Performing these studies is difficult with traditional experimental techniques. fMRI is a noninvasive functional neuroimaging technique that simultaneously examines the subcortex and cortex, making it suited to both needs. fMRI has been used extensively to study auditory system function. Preliminary data suggests that fMRI is sensitive to functional changes following moderate exposure.


Project number9042154
Grant typeGRF
Effective start/end date1/07/1315/05/17