Evolving New L-RNA Aptamers and Developing L-RNA aptamer-peptide Conjugates to Control G-quadruplex Structure-associated Gene Activity

Project: Research

Research Output

  1. 2023
  2. Published

    Selective targeting of parallel G-quadruplex structure using L-RNA aptamer

    Ji, D., Yuan, J., Chen, S., Tan, J. & Kwok, C. K., 27 Nov 2023, In: Nucleic acids research. 51, 21, p. 11439-11452

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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  3. Published

    Modified nucleic acid aptamers: development, characterization, and biological applications

    Ji, D., Feng, H., Liew, S. W. & Kwok, C. K., Nov 2023, In: Trends in Biotechnology. 41, 11, p. 1360-1384 25 p.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 9
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  4. Published

    Peptides Selected by G4-mRNA Display-Seq Enable RNA G-Quadruplex Recognition and Gene Regulation

    Mou, X. & Kwok, C. K., 30 Aug 2023, In: Journal of the American Chemical Society. 145, 34, p. 18693–18697

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 4
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  5. Published

    A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression

    Lyu, K. & Kwok, C. K., 7 Jul 2023, In: Chemical Communications. 59, 53, p. 8230-8233

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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  6. Published

    Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19

    Zhang, Y., Juhas, M. & Kwok, C. K., Apr 2023, In: Trends in Biotechnology. 41, 4, p. 528-544

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 28
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  7. Published

    Tuning Material States and Functionalities of G-Quadruplex-Modulated RNA-Peptide Condensates

    Guo, W., Ji, D., Kinghorn, A. B., Chen, F., Pan, Y., Li, X., Li, Q., & 3 othersHuck, W. T. S., Kwok, C. K. & Shum, H. C., 1 Feb 2023, In: Journal of the American Chemical Society. 145, 4, p. 2375–2385

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 6
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  8. Published

    RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays

    Lyu, K. & Kwok, C. K., 2023, In: Methods in Enzymology. 691, p. 63-80 18 p.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 1
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  9. 2022
  10. Published

    An RNA G-Quadruplex Structure within the ADAR 5’UTR Interacts with DHX36 Helicase to Regulate Translation

    Lyu, K., Chen, S., Chow, E. Y., Zhao, H., Yuan, J., Cai, M., Shi, J., & 3 othersChan, T., Tan, J. & Kwok, C. K., 23 Dec 2022, In: Angewandte Chemie (International Edition). 61, 52, e202203553.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 6
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  11. Published

    Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application

    Lam, S. Y., Lau, H. L. & Kwok, C. K., Dec 2022, In: Biosensors. 12, 12, 1142.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 11
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  12. Published

    Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0

    Zhao, J., Chow, E. Y., Yeung, P. Y., Zhang, Q. C., Chan, T. & Kwok, C. K., 2022, In: BMC Biology. 20, 257.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 7
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