Effects of Lewis Acids on Osmium Catalyzed Oxidation of Organic Compounds

Project: Research

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This project aims to study the oxidation of organic substrates using a catalytic system that consists of a Lewis acid and an osmium nitrido species. The researchers have previously discovered that certain metal oxo species that are normally unreactive, such as [Os(N)(O)3]-, can be activated by Lewis acids to become strong oxidants. In this project they will use this concept to develop efficient catalytic processes for the selective oxidation of various organic substrates, including alkanes, aromatic compounds, and alcohols. Environmentally friendly oxidants such as hydrogen peroxide and readily available oxidants such as tert-butyl hydroperoxide will be used as terminal oxidants. Alkanes are the main constituents of petroleum, and the search for efficient and selective methods to functionalize this inert raw material under mild conditions continues to be a challenge for chemists. Ring oxidation of aromatic hydrocarbons results in the formation of phenols, hydroquinones, and quinones, which are valuable intermediates for the construction of products ranging from polymers to pharmaceuticals. The oxidation of alcohols to carbonyl compounds is one of the most important transformations in organic chemistry. These studies should provide a new approach for the selective catalytic oxidation of organic substrates under mild conditions.


Project number9041201
Grant typeGRF
Effective start/end date1/09/0731/05/11