Effect of Electrical Activity on Animal Model of Optic Nerve Regeneration
DescriptionAxon fails to regenerate after central nervous system (CNS) injures. Overcoming the obstacle for functional recovery has become the major target of neuroscience. Different mechanisms have been suggested that govern axon regeneration. Blocking extracellular inhibitory alone has been reported to be insufficient to allow injured axons to regenerate. Significant progress has been made in understanding the intrinsic cellular and molecular mechanisms for regulating axon regeneration. Recently, replacing lost neurons or connections with artificial electric circuits that interface with the nervous system has gained attentions to induce neuronal survival and regeneration, particularly in retinal ganglion cells. The retinal prosthesis and cochlear implant have proved the concept of restoring lost neuronal functions by artificial means. This proposed project aims at investigating the effect of electrical stimulation together with heat shock protein protection to promote axon regeneration after optic nerve injury.
|Effective start/end date||1/05/12 → 3/03/15|