Development of Novel Biodegradable Metallic Materials for Orthopedics
DescriptionThe development of biodegradable materials is a desirable advancement for implants used during surgical intervention for patients with complicated bone fracture or deformity. Among various biodegradable materials, metallic materials such as magnesium alloys are still preferable for orthopaedic implantation, as the mechanical properties of these alloys are closer to the human bone. The major obstacles to their use are their rapid degradation inside the human body, and hydrogen gas release on degradation.The researchers’ previous work has demonstrated that plasma immersion ion implantation (PIII) surface treatment is a feasible way to enhance the corrosion resistance of magnesium alloys, with a fourfold increase in the anti-corrosion properties. However, little information is known about the mechanical and biomechanical integrity of these PIII-treated magnesium alloys, the cyto-toxic effects of released ions, and hydrogen gas release under in vivo conditions. This project aims to conduct mechanical, biomechanical, short-term and long-term in vitro and in vivo biological studies of plasma-modified magnesium alloys. If the outcome is favourable, it may revolutionize the future development of orthopaedic implants, benefiting patients worldwide, and eliminating the risks of having a metallic implant left inside the body, or the need to remove it with further surgery.
|Effective start/end date||1/01/08 → 27/05/09|