Development of Gut-targeted Anti-multiple Sclerosis Bismuth Peroxides Drugs
DescriptionDysbiosis, or imbalances in the gut microbiota and intestinal inflammation have been linked to multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Gastroprotective bismuth compounds demonstrate a great clinical promise as microbiota-associated immunomodulatory compounds. However, the potential of bismuth compounds in modulating ‘gut-central nervous system (CNS) axis’ therefore affecting autoimmunity has never been investigated. In this proposal, we aim to evaluate whether we can restore peripheral tolerance in EAE mice by exogenously administrating novel bismuth drug candidates, and if so, what is the underlying molecular mechanism? The current application seeks funding to generate high-quality preliminary data in support of our analysis of novel bismuth drug candidates in gut health and autoimmunity. These proposed studies will help researchers devise methods to restore tolerance in MS/EAE.
|Effective start/end date||1/05/22 → …|