Development of an Integrated Microfluidics System for Multi-level High Content Screening of Anti-tumor Drugs - RMGS

Description

It is very important to develop and adopt efficient and cost-effective screening technologies for anti-cancer drug screening. There is a great demand for new high-throughput and high-content platforms that would reduce reagent consumption and mimic the in vivo environment to which cancer cells are exposed, for efficient screening of potential drug candidates. Our projects aims to develop an integrated microfluidics system that mimics the physiological and pathological micro environments to simulate the in vivo conditions of cell growth, communication, and migration, for high-throughput and high-content screening of drugs targeting/affecting cell-cell interactions and drugs/drug combinations that may alter/interfere with the cell-cell interactions occurring during tumor metastasis. This development will offer a novel tool for efficient drug screening with reduced drug development time and cost, and be beneficial to pharmaceutical companies as well as patients and society.