Development of A Neural Motor Prosthesis Prototype for Restoration of Motor Function in Animal

Project: ResearchARG

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Neural prosthesis, also named as brain machine interface, are devices that aim to improve functional outcomes in patient with neurodegenerative diseases or damages in the nervous system. The emerging field of neuroprosthetics is focused on developing therapeutic interventions that able to improve patient’s motor functional outcomes and therefore their quality of life. Cerebellum is the motor coordination center of the brain which control fine body movement and balance. In current study, we will record the neural spike firing pattern of deep cerebellar nuclei (DCN) in cerebellum and electromyography (EMG) of muscle at different states of locomotion on the same animal simultaneously to generate a motor map. Motor map obtained will provide a mathematical model relating DCN firing pattern and phases of locomotion identified by EMG. We will then develop and validate a real-time hardware DCN pacemaker prototype. Finally, we will test if this field-programmable gate array (FPGA)-based prototype will serve as a DCN pacemaker to improve the motor coordination in animal model of drug-induced motor deficit. Knowledge obtained from current project will shed new light on the development of neuroprosthetics and neurorehabilitation strategies for improving treatment of neurodegenerative diseases.


Effective start/end date1/06/17 → …