Deficient MHC Class I and Adaptive Immune Response in Lung Cancer

Project: Research

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Description

Lung cancer is the most common cancer and a leading cause of cancer-related death worldwide. Immunotherapy is emerging as an important approach to treat lung cancer, however, effective only in a subset of lung cancer patients. We hypothesized that MHC Class I deficient tumors may be associated with resistance to immunotherapy due to their inability to present endogenous tumor neoantigens to cell surface for recognition by cytotoxic T lymphocytes. Thus, tumor MHC Class I gene mutation status could predict T cell clonal expansion and to further serve as a biomarker for checkpoint blockade therapy. Our objectives are: 1) to assess the association between the mutational status of genes involved in MHC Class I and T cell infiltration into the tumor area; 2) top validate the functional effects of mutant genes identified in the first Objective, 3) to evaluate in patient samples whether mutations in MHC class I genes could affect proliferation of CD8+T cell.

Detail(s)

Project number7004596
Grant typeSRG-Fd
StatusFinished
Effective start/end date1/09/1621/01/19