Deciphering Long Non-coding RNA Structures, Interactions, and their Functions in Skeletal Myogenic Differentiation

Search results

• 2026

  Computational Analysis Uncovering Contrasts in G-Quadruplex Propensity and Aptamer Enrichment in SELEX-Derived Libraries

  Liu, G., Wu, T.-Y., Kwok, C. K. & Liu, J., Jan 2026, In: ChemBioChem. 27, 1, 13 p., e202500614.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  • Aptamer 100%
  • Systematic Evolution of Ligands by Exponential Enrichment 100%
  • Evolutionary Biology 100%
  • Evolution 100%
  • Binding Affinity 33%

• 2025

  A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo

  Liew, S. W., Cao, D., Petersen, R. J., Butcher, S. E., Kennedy, S. G. & Kwok, C. K., 24 Mar 2025, In: Nucleic Acids Research. 53, 5, gkaf137.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • RNA 100%
  • Gene Expression 100%
  • Aptamer 100%
  • Caenorhabditis Elegans 33%
  • Gene Inactivation 33%

  2   Link opens in a new tab Citations (Scopus)

  46 Downloads (CityUHK Scholars)

• DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights

  Chen, X. (Co-first Author), Yang, F. (Co-first Author), Zhang, S. (Co-first Author), Guo, X., ZHAO, J., Qiao, Y., He, L., Li, Y., Zhou, Q., Ong, M.T.-Y., KWOK, C. K., Sun, H. & Wang, H., 2025, In: Genome Biology. 26, 33 p., 269.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • Skeletal Muscle 100%
  • Stem Cell 100%
  • Cell Activation 30%
  • Chromatin 20%
  • Promoter Region 20%

  29 Downloads (CityUHK Scholars)

• ebv-sisRNA-3 contributes to the formation of G4-associated R-loop upstream of EBV lytic replication origin in latently infected cells

  Wang, B., Chung, G. T. Y., Shuai, Y., Wu, M., Ji, D., Lung, R. W. M., Chan, Y. Y., Liu, M. T., Kong, E. L., Hui, S. Y., Leung, H. M., Wu, Q., Chan, M. S. A., Wang, X., Zhu, G., Yip, K. Y., Kwok, C. K., Lo, K. W. & Tsang, C. M., 2025, In: Cell & Bioscience. 15, 91.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • DNA Replication Origin 100%
  • Epstein Barr Virus 100%
  • Ribonucleic Acid 11%
  • Viral Protein 5%
  • Cancer Cell 5%

  17 Downloads (CityUHK Scholars)

• G4-SLSELEX-Seq-driven discovery of a G4-specific targeting L-RNA aptamer with unique structural features

  Wu, T.-Y. & Kwok, C. K., 21 Nov 2025, In: Organic & Biomolecular Chemistry. 23, 43, p. 9851-9856 6 p.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  • RNA 100%
  • Aptamer 100%
  • Binding Affinity 33%
  • Protein Interaction 33%

  1   Link opens in a new tab Citation (Scopus)

• L-RNA Aptamer-Based Tools for G-Quadruplex Structure: Identification, Characterization, and Application

  Ji, D. (Co-first Author), Zhang, K. (Co-first Author), Yarshova, M. (Co-first Author) & Kwok, C. K., 4 Nov 2025, In: Accounts of Chemical Research. 58, 21, p. 3247–3258 12 p.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • RNA 100%
  • Aptamer 100%
  • Systematic Evolution of Ligands by Exponential Enrichment 16%
  • Transcription 11%
  • Single-Stranded DNA 5%

  1 Downloads (CityUHK Scholars)

• MoRNiNG: A Database of RNA Modification Sites Associated with RNA Secondary Structure Dynamics

  Zhou, Y. (Co-first Author), Lyu, S. (Co-first Author), Liew, S. W. (Co-first Author), Mao, X., Hoffecker, I., Yan, J., Li, Y., Kwok, C. K. & Zhang, J., 14 Nov 2025, (Online published) In: Genomics, Proteomics and Bioinformatics.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  • Protein Secondary Structure 100%
  • RNA 100%
  • RNA Modification 100%
  • RNA Structure 83%
  • Transcriptome 33%

• Nucleic acid-guided protein-empowered aquatic contaminants sensing

  Zhang, F. (Co-first Author), Liew, S. W. (Co-first Author), Lam, S. Y. (Co-first Author) & Kwok, C. K., Dec 2025, In: Trends in Chemistry. 7, 12, p. 853-868

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  • Nucleic Acid 100%
  • Argonaute 25%
  • CRISPR-Cas12A 25%
  • One Health 25%
  • Artificial Intelligence 25%

• Quadrupia provides a comprehensive catalog of G-quadruplexes across genomes from the tree of life

  Chantzi, N. (Co-first Author), Nayak, A. (Co-first Author), Baltoumas, F. A. (Co-first Author), Aplakidou, E., Liew, S. W., Galuh, J. E., Patsakis, M., Montgomery, A., Moeckel, C., Mouratidis, I., Sazed, S. A., Guiblet, W., Karmiris-Obratański, P., Wang, G., Zaravinos, A., Vasquez, K. M., Kwok, C. K., Pavlopoulos, G. A. & Georgakopoulos-Soares, I., Nov 2025, In: Genome Research. 35, 11, p. 2578-2600 23 p.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • DNA Replication Origin 100%
  • Melting Point 100%
  • Taxon 100%
  • Biological Phenomena and Functions Concerning the Entire Organism 100%
  • Hidden Markov Model 100%

  3   Link opens in a new tab Citations (Scopus)

  2 Downloads (CityUHK Scholars)

• 2024

  Specific Targeting and Imaging of RNA G-Quadruplex (rG4) Structure Using Non-G4-Containing l-RNA Aptamer and Fluorogenic l-Aptamer

  Lau, H. L., Zhao, H., Feng, H. & Kwok, C. K., 3 Sept 2024, (Online published) In: Small Methods. 2401097.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • RNA 100%
  • Aptamer 100%
  • Amyloid Precursor Protein 66%
  • Binding Affinity 22%
  • Biological Phenomena and Functions Concerning the Entire Organism 11%

  1   Link opens in a new tab Citation (Scopus)

  8 Downloads (CityUHK Scholars)

• 2023

  A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression

  Lyu, K. & Kwok, C. K., 7 Jul 2023, In: Chemical Communications. 59, 53, p. 8230-8233

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • MicroRNA 100%
  • Gene Expression Control 100%
  • Messenger RNA 100%
  • Gene Expression 100%
  • Ribonucleic Acid 100%

  4   Link opens in a new tab Citations (Scopus)

  44 Downloads (CityUHK Scholars)

• 2021

  Discovery of G-quadruplex-forming sequences in SARS-CoV-2

  Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y., Mar 2021, In: Briefings in Bioinformatics. 22, 2, p. 1150-1160 11 p.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  • Virus 100%
  • Docking (Molecular) 100%
  • Open Reading Frame 100%
  • Coronavirinae 100%
  • Coronaviridae 100%

  91   Link opens in a new tab Citations (Scopus)

• Proteomic and Transcriptome Profiling of G-Quadruplex Aptamers Developed for Cell Internalization

  Zhang, Y., Wu, Y., Zheng, H., Xi, H., Ye, T., Chan, C.-Y. & Kwok, C. K., 13 Apr 2021, In: Analytical Chemistry. 93, 14, p. 5744-5753

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  • Gene Expression Profiling 100%
  • Internalization 100%
  • Aptamer 100%
  • Proteomics 100%
  • Nucleic Acid 57%

  15   Link opens in a new tab Citations (Scopus)

• Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

  Chen, X., Yuan, J., Xue, G., Campanario, S., Wang, D., Wang, W., Mou, X., Liew, S. W., Umar, M. I., Isern, J., Zhao, Y., He, L., Li, Y., Mann, C. J., Yu, X., Wang, L., Perdiguero, E., Chen, W., Xue, Y. & Nagamine, Y. & 4 others, Kwok, C. K., Sun, H., Muñoz-Cánoves, P. & Wang, H., 2021, In: Nature Communications. 12, 5043.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • Stem Cell 100%
  • DHX36 100%
  • Muscle Regeneration 37%
  • Cell Proliferation 25%
  • Cell Expansion 25%

  60   Link opens in a new tab Citations (Scopus)

  61 Downloads (CityUHK Scholars)

• 2020

  Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction

  Mou, X. & Kwok, C. K., 17 Dec 2020, In: Biochemical and Biophysical Research Communications. 533, 4, p. 1135-1141

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  • RNA Sequence 100%
  • Peptide 100%
  • RNA 40%
  • Binding Protein 20%
  • Chirality 20%

  6   Link opens in a new tab Citations (Scopus)

• rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments

  Chow, E.Y.-C., Lyu, K., Kwok, C. K. & Chan, T.-F., 2020, In: RNA Biology. 17, 7, p. 903-917

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • RNA 100%
  • Bioinformatics 100%
  • Transcriptome 50%

  22   Link opens in a new tab Citations (Scopus)

  67 Downloads (CityUHK Scholars)

• RNA G-quadruplex structures exist and function in vivo in plants

  Yang, X., Cheema, J., Zhang, Y., Deng, H., Duncan, S., Umar, M. I., Zhao, J., Liu, Q., Cao, X., Kwok, C. K. & Ding, Y., 2020, In: Genome Biology. 21, 226.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • RNA 100%
  • Arabidopsis 18%
  • Guanine 18%
  • Protein Secondary Structure 9%
  • Genetics 9%

  103   Link opens in a new tab Citations (Scopus)

  82 Downloads (CityUHK Scholars)

• RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria

  Shao, X., Zhang, W., Umar, M. I., Wong, H. Y., Seng, Z., Xie, Y., Zhang, Y., Yang, L., Kwok, C. K. & Deng, X., Jan 2020, In: mBio. 11, 1, e02926-19.

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • RNA 100%
  • Gene Control 100%
  • Bacterium 100%
  • Ribonucleic Acid 100%
  • Escherichia coli 50%

  66   Link opens in a new tab Citations (Scopus)

  126 Downloads (CityUHK Scholars)

• Specific Binding of a D-RNA G-Quadruplex Structure with an L-RNA Aptamer

  Chan, C.-Y. & Kwok, C. K., 23 Mar 2020, In: Angewandte Chemie - International Edition. 59, 13, p. 5293-5297

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  • RNA 100%
  • Aptamer 100%
  • Protein Secondary Structure 20%
  • Gene Control 20%

  44   Link opens in a new tab Citations (Scopus)

• Specific suppression of D-RNA G-quadruplex-protein interaction with an L-RNA aptamer

  Umar, M. I. & Kwok, C. K., 9 Oct 2020, In: Nucleic Acids Research. 48, 18, p. 10125-10141

  Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

  Open Access

  File

  • RNA 100%
  • Protein Interaction 100%
  • Aptamer 100%
  • Nucleic Acid Structure 16%
  • Binding Protein 16%

  45   Link opens in a new tab Citations (Scopus)

  86 Downloads (CityUHK Scholars)