Controlled Surface Micro- and Nano-patterning of Biomaterials for Enhanced Biological Properties
- Paul Kim Ho CHU (Principal Investigator / Project Coordinator)Department of Physics
- Nathan W CHEUNG (Co-Investigator)
DescriptionSurface topography and functionalization are known to play important roles in biological cell orientation and biocompatibility of biomaterials. Artificial micro- and nano-patterns on the surface can influence the behaviour of cells such as cell adhesion, orientation, movement, growth, and activation. This research project aims at exploring novel surface topography designs and processes in conjunction with surface chemical functional group incorporation to sort, steer, and enhance the proliferation of biological cells at specific spatial locations on a substratum and to enhance the biological properties of biomaterials. Micro- and nano-surface lithographic techniques and plasma surface processing will be used to engineer self-organized patterns and chemical functional groups. The developed technology will be applied to important biomedical applications such as artificial cardiovascular materials. Proper endothelialization of cardiovascular device surfaces can prevent thrombogenicity as a confluent monolayer of healthy endothelial cells represents the ideal nonthrombogenic blood-contacting surface in blood vessels. The researchers will design and fabricate micro- and nano-patterns to optimize endothelialization on biomaterials such as titanium oxide and diamond-like carbon to mitigate thrombosis and blood platelet deposition. Extension of this project can possibly lead to manipulation of biological species with pixel-to-pixel accuracy by means of electrostatic, photonic, and nano-fluidic stimulation.
|Effective start/end date||1/01/08 → 14/02/11|