CMOS Dual Fluorescence-electrochemical Sensory Microsystem Platform for Medical Diagnostics
DescriptionWith the global aging population, demand for accurate, rapid, and low-cost medical diagnosticshas been ever rising. Medical diagnostics, based on the detection of biomolecules such as DNAand protein, has wide applications from viral and pathogenic screening to genetic and cancerstudies.Fluorescence and electrochemical methods are commonly used in biomolecule detection.Conventionally, fluorescence and electrochemical detections are performed by the bench-topfluorimeter and potentiostat, respectively. Both instruments typically consist of discretecomponents, making them bulky and expensive. Due to the sequential nature of the instrument,the throughput is generally low.In this project, we propose to design, prototype, and experimentally validate a novel dualfluorescence-electrochemical sensory microsystem. Executing both detection strategies usingone platform reduces sample volume, simplifies instrumental procedures, and enables newcapabilities such as improves reliability and accuracy. In the microsystem, a CMOS sensor arrayserves as the sensory and computational core. There are two major novelties. First, high level ofmicrosystem integration enables the support of fluorescence, electrochemical, andelectrochemiluminescence applications with a single device. Second, a shot-noise awaresuccessive-approximation analog-to-digital converter architecture enables low-power readout.The proposed highly-integrated, low-power sensory platform will enable novel implementationof disposable, wearable, and implantable biosensors that not only address key unmet needs inubiquitous medical diagnostics, but can also be used as enabling research vehicles for the more general applications in biology and medicine.
|Effective start/end date||1/01/15 → 21/12/18|
- CMOS integrated circuit,CMOS sensory microsystem,CMOS fluorescence detection,Low-power sensor readout,