Biomarker Based Brain Stimulation Treatment for Autism Spectrum Disorder (ASD): A Feasibility Study on Modulating the Sensitivity of Individuals with Autistic Traits to Changes in Emotional and Non-emotional Cues with Transcranial Electric Stimulation (tES)

Project: Research

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Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder. While ASD diagnoses are made based on the patients’ behavioral symptoms, ASD treatments are purely symptomatic. The lack of biomarker and treatment targeting the core deficits in the underlying brain mechanisms have posted significant challenges in the management of ASD. The PC’s research group previously developed a paradigm to elicit a brain response called the mismatch negativity (MMN) that is sensitive to individuals with ASD symptoms. Next, they will combine this biomarker with an non-invasive brain stimulation method, the transcranial electric stimulation (tES), to monitor the treatment progress while directly modulating the neural activities underlying ASD. This proposal aims at developing the tES treatment protocols to modulate specific MMN responses and demonstrating the feasibility in using tES for ASD treatment. The results of the proposed study will be the foundation for a biomarker based brain stimulation treatment for ASD. 


Project number7020025
Grant typeSIRG
Effective start/end date30/06/21 → …