Asymmetric Electrochemical Hydrogenation

Project: Research

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Description

Electro-organic synthesis is one of the most prominent pathways toward sustainable and environmentally benign synthetic chemistry. The combination of electrochemical synthesis with other newly developed synthetic techniques is extremely attractive to chemists. The asymmetric hydrogenation reaction is of practical significance in industry, because it shows a strong ability to construct various chiral motifs for drug synthesis. Therefore, it piques our interest to combine asymmetric hydrogenation with electrochemical synthesis to develop asymmetric electrochemical hydrogenations. Although electrochemical reductions have been widely explored, research on electrochemical hydrogenation hasn’t been extensively studied and especially asymmetric electrochemical hydrogenation is scarce. The compatibility and distinctive mechanisms of these two component reactions pose significant challenges to their successful adoption. In the propose project, we aim to use electricity and water as a replacement for traditional pressurized H2 in asymmetric hydrogenation. Strategies from indirect and direct electrolysis pathways are proposed, including chiral mediators, chiral organocatalysts and organometallic catalysts. From the mechanistic aspect, these strategies show totally different reaction pathways compared with traditional asymmetric hydrogenation. This proposed project will provide both practical meaning and a theoretical perspective of the electrochemical asymmetric hydrogenations.

Detail(s)

Project number9048310
Grant typeECS
StatusNot started
Effective start/end date1/01/25 → …