A Mid-infrared Spectroscopic Microscope Utilizing On-chip Supercontinuum Generation
DescriptionThis project aims to develop a mid-infrared spectroscopic microscope capable of improved biomolecular identification and three-dimensional structural imaging. This microscope will be able to recognize many important biomolecules including protein, lipid, nucleic acid and carbohydrate through the characteristic molecular fingerprint spectral absorption in the mid-infrared wavelengths ranging between 2μm and 15μm. The traditional spectroscopic microscope faces challenges for practical implementation because of the prohibitively expensive broadband mid-infrared light, while in contrast, this project will deliver a chalcogenide-glass-based single chip with an on-chip mid-infrared light, delivering low-cost, portable, mass-producible high quality broadband mid-infrared light source for spectroscopic microscope applications in physiology, biology and medicine. The on-chip mid-infrared light is sourced from the recent success of broadband mid-infrared supercontinuum generation via integrated highly nonlinear chalcogenide waveguide. The chalcogenide glasses are a family of glasses containing one or more chalcogen elements which are of highly nonlinearity, negligible nonlinear absorption and excellent mid-infrared transparency. This project aims to further optimize the on-chip chalcogenide waveguide via comprehensive material study and advanced nano-fabrication, tailoring the performance of the mid-infrared supercontinuum generation toward to the practical applications on critical properties including spectral coverage, output power, brightness, stability and coherence. This project will deliver a cost-effective spectroscopic microscope with enhanced detection and imaging capabilities. For the first time, this will make high quality spectroscopic imaging accessible to a broad range of researchers and medical clinicians. The success of this project will also pave the way towards miniaturized on-chip spectroscopic microscope for wearable medical diagnosis at biomolecular level. The project will position Hong Kong at the forefront of this emerging field, with significant commercialization opportunities.
|Effective start/end date||1/01/20 → …|