Dr. ZHENG Zongli (鄭宗立)

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Research Output

  1. 2022
  2. Published

    High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination

    Yuen, C. T. L., Thean, D. G. L., Chan, B. K. C., Zhou, P., Kwok, C. C. S., Chu, H. Y., Cheung, M. S. H., & 7 othersWang, B., Chan, Y. M., Mak, S. Y. L., Leung, A. Y., Choi, G. C. G., Zheng, Z. & Wong, A. S. L., 22 Feb 2022, In: Nucleic Acids Research. 50, 3, p. 1650-1660

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 2
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  3. Published

    Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC

    Song, Z., Lian, S., Mak, S., Chow, M. Z., Xu, C., Wang, W., Keung, H. Y., & 7 othersLu, C., Kebede, F. T., Gao, Y., Cheuk, W., Cho, W. C. S., Yang, M. & Zheng, Z., Feb 2022, In: Journal of Thoracic Oncology. 17, 2, p. 264-276 13 p.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 8
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  4. Accepted/In press/Filed

    Methods and systems for measuring multiplex RNA expression

    ZHENG, Z. & LU, C., 28 Jan 2022, (Accepted/In press/Filed) Priority No. 63/304,489

    Research output: Patents, Agreements and Assignments (RGC: 51, 52, 53) › 51_Patents granted (CityU only, data source from KTO)

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  5. Published

    Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities

    Thean, D. G. L., Chu, H. Y., Fong, J. H. C., Chan, B. K. C., Zhou, P., Kwok, C. C. S., Chan, Y. M., & 5 othersMak, S. Y. L., Choi, G. C. G., Ho, J. W. K., Zheng, Z. & Wong, A. S. L., 2022, In: Nature Communications. 13, 2219.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 2
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  6. 2021
  7. Published

    Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seq

    Malinin, N. L., Lee, G., Lazzarotto, C. R., Li, Y., Zheng, Z., Nguyen, N. T., Liebers, M., & 6 othersTopkar, V. V., Iafrate, A. J., Le, L. P., Aryee, M. J., Joung, J. K. & Tsai, S. Q., Dec 2021, In: Nature Protocols. 16, 12, p. 5592–5615

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 6
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  8. Published

    Efficacy of Loop-Mediated Isothermal Amplification for H. pylori Detection as Point-of-Care Testing by Noninvasive Sampling

    Sohrabi, A., Franzen, J., Tertipis, N., Zagai, U., Li, W., Zheng, Z. & Ye, W., Sep 2021, In: Diagnostics. 11, 9, 1538.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 1
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  9. Evaluation of endocrine resistance using ESR1 genotyping of circulating tumor cells and plasma DNA

    Sundaresan, T. K., Dubash, T. D., Zheng, Z., Bardia, A., Wittner, B. S., Aceto, N., Silva, E. J., & 7 othersFox, D. B., Liebers, M., Kapur, R., Iafrate, J., Toner, M., Maheswaran, S. & Haber, D. A., Jul 2021, In: Breast Cancer Research and Treatment. 188, 1, p. 43-52

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 3
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  10. Published

    Modified Protein And Method for Altering Genome of Cell

    SHI, J., ZHENG, Z. & TAN, Y., 13 Apr 2021, Patent No. US10,975,364, Priority No. 16/552,034

    Research output: Patents, Agreements and Assignments (RGC: 51, 52, 53) › 51_Patents granted (CityU only, data source from KTO)

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  11. Published

    Noncanonical Gene Fusions Detected at the DNA Level Necessitate Orthogonal Diagnosis Methods Before Targeted Therapy

    Song, Z., Lu, C., Xu, C. & Zheng, Z., Mar 2021, In: Journal of Thoracic Oncology. 16, 3, p. 344-348

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › Editorial Preface

    Scopus citations: 5
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  12. 2020
  13. Published

    A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets

    Zhou, P., Chan, B. K., Wan, Y. K., Yuen, C. T., Choi, G. C., Li, X., Tong, C. S., & 13 othersZhong, S. S. W., Sun, J., Bao, Y., Mak, S. Y. L., Chow, M. Z. Y., Khaw, J. V., Leung, S. Y., Zheng, Z., Cheung, L. W. T., Tan, K., Wong, K. H., Chan, H. Y. E. & Wong, A. S. L., 11 Aug 2020, In: Cell Reports. 32, 6, 108020.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 15
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  14. Published

    Cancer-associated histone mutation H2BG53D disrupts DNA-histone octamer interaction and promotes oncogenic phenotypes

    Wan, Y. C. E., Leung, T. C. S., Ding, D., Sun, X., Liu, J., Zhu, L., Kang, T. Z. E., & 13 othersYang, D., Zhang, Y., Zhang, J., Qian, C., Huen, M. S. Y., Li, Q., Chow, M. Z. Y., Zheng, Z., Han, J., Goel, A., Wang, X., Ishibashi, T. & Chan, K. M., 2020, In: Signal Transduction and Targeted Therapy. 5, 27.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › Letter › peer-review

    Scopus citations: 11
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  15. 2019
  16. Published

    Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity

    Tan, Y., Chu, A. H., Bao, S., Hoang, D. A., Kebede, F. T., Xiong, W., Ji, M., & 2 othersShi, J. & Zheng, Z., 15 Oct 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 42, p. 20969-20976

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 50
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  17. Published

    Bone Sarcoma With EWSR1-NFATC2 Fusion: Sarcoma With Varied Morphology and Amplification of Fusion Gene Distinct From Ewing Sarcoma

    Yau, D. T. W., Chan, J. K. C., Bao, S., Zheng, Z., Lau, G. T. C. & Chan, A. C. L., Aug 2019, In: International Journal of Surgical Pathology. 27, 5, p. 561–567

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 13
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  18. Published

    Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9

    Choi, G. C. G., Zhou, P., Yuen, C. T. L., Chan, B. K. C., Xu, F., Bao, S., Chu, H. Y., & 5 othersThean, D., Tan, K., Wong, K. H., Zheng, Z. & Wong, A. S. L., Aug 2019, In: Nature Methods. 16, 8, p. 722–730

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 28
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  19. Highly Multiplexed Fluorescence in Situ Hybridization for in Situ Genomics

    Onozato, M. L., Yapp, C., Richardson, D., Sundaresan, T., Chahal, V., Lee, J., Sullivan, J. P., & 11 othersMadden, M. W., Shim, H. S., Liebers, M., Ho, Q., Maheswaran, S., Haber, D. A., Zheng, Z., Clancy, B., Elliott, H. L., Lennerz, J. K. & Iafrate, A. J., May 2019, In: Journal of Molecular Diagnostics. 21, 3, p. 390-407

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 8
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  20. 2018
  21. Accepted/In press/Filed

    Enrichment and determination of nucleic acids targets

    ZHENG, Z. & KEBEDE, F. T., 7 Aug 2018, (Accepted/In press/Filed) Priority No. 16/057,004

    Research output: Patents, Agreements and Assignments (RGC: 51, 52, 53) › 51_Patents granted (CityU only, data source from KTO)

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  22. Artificial Intelligence Approach for Variant Reporting

    Zomnir, M. G., Lipkin, L., Pacula, M., Dominguez Meneses, E., MacLeay, A., Duraisamy, S., Nadhamuni, N., & 8 othersAl Turki, S. H., Zheng, Z., Rivera, M., Nardi, V., Dias-Santagata, D., Iafrate, A. J., Le, L. P. & Lennerz, J. K., 22 Mar 2018, In: JCO Clinical Cancer Informatics. 2, 13 p.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 13
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  23. Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor-Positive Breast Cancer

    Matissek, K. J., Onozato, M. L., Sun, S., Zheng, Z., Schultz, A., Lee, J., Patel, K., & 27 othersJerevall, P., Saladi, S. V., Macleay, A., Tavallai, M., Badovinac-Crnjevic, T., Barrios, C., Beşe, N., Chan, A., Chavarri-Guerra, Y., Debiasi, M., Demirdögen, E., Egeli, Ü., Gökgöz, S., Gomez, H., Liedke, P., Tasdelen, I., Tolunay, S., Werutsky, G., St. Louis, J., Horick, N., Finkelstein, D. M., Le, L. P., Bardia, A., Goss, P. E., Sgroi, D. C., Iafrate, A. J. & Ellisen, L. W., Mar 2018, In: Cancer Discovery. 8, 3, p. 336-353

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 26
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  24. 2017
  25. Published

    Unique distribution of programmed death ligand 1 (PD-L1) expression in East Asian non-small cell lung cancer

    Pan, Y., Zheng, D., Li, Y., Cai, X., Zheng, Z., Jin, Y., Hu, H., & 7 othersCheng, C., Shen, L., Wang, J., Ji, H., Sun, Y., Zhou, X. & Chen, H., Aug 2017, In: Journal of Thoracic Disease. 9, 8, p. 2579-2586

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 44
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  26. Recurrent and functional regulatory mutations in breast cancer

    Rheinbay, E., Parasuraman, P., Grimsby, J., Tiao, G., Engreitz, J. M., Kim, J., Lawrence, M. S., & 26 othersTaylor-Weiner, A., Rodriguez-Cuevas, S., Rosenberg, M., Hess, J., Stewart, C., Maruvka, Y. E., Stojanov, P., Cortes, M. L., Seepo, S., Cibulskis, C., Tracy, A., Pugh, T. J., Lee, J., Zheng, Z., Ellisen, L. W., Iafrate, A. J., Boehm, J. S., Gabriel, S. B., Meyerson, M., Golub, T. R., Baselga, J., Hidalgo-Miranda, A., Shioda, T., Bernards, A., Lander, E. S. & Getz, G., 6 Jul 2017, In: Nature. 547, p. 55-60

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

    Scopus citations: 208
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