Personal profile
Author IDs
ORCID iD: 0000-0003-3526-7808
Scopus Author ID: 56148872100
Impact
Qualifications (Brief)
DVM, MPVM, PhD
Biography
Prof. Chen received his veterinary degree in 1997 and a Master of Preventive Veterinary Medicine degree in 2000, both from the China Agriculture University. He completed his PhD in Food Microbiology at the University of Maryland, USA, in 2004, and his postdoctoral training in the Department of Microbiology and Molecular Genetics at the Medical College of Wisconsin, USA, in 2009. Before joining City University of Hong Kong in 2019, he had spent 10 years working in the Department of Applied Biology and Chemical Technology at the Hong Kong Polytechnic University as Assistant Professor, Associate Professor and Professor.
Prof. Chen participates in the Hong Kong government’s policy making through an ad-hoc working group on microbial guidelines for ready-to-eat food under the Department of Food and Environmental Hygiene of Hong Kong Government. He is also a member of the Shenzhen Expert Committee to help the Shenzhen government’s decision making on the development of biotechnologies. He has established and served as the Director of the Shenzhen Key Laboratory for Food Biological Safety Control before joining CityU.
Research Interests/Areas
Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields. His research lies on the interface of clinical study and basic science using multi-disciplinary approaches including Genomics, Genetics, Biochemistry, Cell Biology and Chemical Biology with the ultimate goal of developing novel therapies to combat bacterial antimicrobial resistance
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger
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SDG 3 Good Health and Well-being
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SDG 12 Responsible Consumption and Production
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SDG 13 Climate Action
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SDG 14 Life Below Water
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SDG 16 Peace, Justice and Strong Institutions
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Collaborations from the last five years
Research output
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Hydrogenase-mediated metabolic functions contribute to formation of bacterial antibiotic tolerance through regulating redox homeostasis and maintaining membrane potential
Zheng, J., Wan, Y., Tang, Y., Chan, E. W. C. & Chen, S., Jan 2026, In: International Journal of Biological Macromolecules. 335, Part 1, 149282.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Novel Antimicrobial Nano Bacteriocin: Lactic Acid Bacteria-Derived, Self-Assembled, and Enhanced for Superior Antimicrobial Activity
Yi, L. (Co-first Author), Li, S. (Co-first Author), Xie, M. (Co-first Author), Chen, B., Chen, K., Wang, Z., Zeng, M., Zhao, Q., Yang, J., Tang, Y., Zhao, W., Zeng, P., Li, X., Wang, J., Zeng, K., Zhong, Y. & Chen, S., 3 Mar 2026, In: Advanced Materials. 38, 13, 19 p., e11782.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Anti-Bacterial Application Of Pz-128
CHEN, S. (Inventor), TANG, Y. (Inventor) & YANG, C. (Inventor), 2 Jul 2025, (Accepted/In press/Filed) Priority No. 63/837,154Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Anti-Bacterial Application Of Uc-112
CHEN, S. (Inventor), TANG, Y. (Inventor) & YANG, C. (Inventor), 1 Jul 2025, (Accepted/In press/Filed) Priority No. 63/837,085Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Antimicrobial effect of sulconazole in combination with glucose/trehalose against carbapenem-resistant hypervirulent Klebsiella pneumoniae persisters
Xie, M., Chen, K., Heng, H., Chan, E.W.-C. & Chen, S., Mar 2025, In: Microbiological Research. 292, 128006.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open Access1 Link opens in a new tab Citation (Scopus)
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SZNSFC-KP-SRI: 基2020N114 耐药靶酶新型抑制剂研究
CHEN, S. (Principal Investigator / Project Coordinator), 程启朋 (Co-Investigator), 许晨 (Co-Investigator), 谢苗苗 (Co-Investigator), 陈维智 (Co-Investigator) & 陈维智 (Co-Investigator)
24/11/20 → …
Project: Research
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DON_RMG: One Health Approaches to Pathogen Detection and Control Technology - RMGS
YANG, M. (Principal Investigator / Project Coordinator), CHEN, S. (Co-Investigator), DENG, X. (Co-Investigator), LAU, C. K. T. (Co-Investigator), LI, R. (Co-Investigator) & LI, J. (Co-Investigator)
1/09/20 → …
Project: Research
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GRF: Combinational Effects of Specific Proton Motive Force (PMF) Dissipators and Metabolites on Re-sensitizing Bacterial Persisters to Antibiotics and the Underlying Mechanisms
CHEN, S. (Principal Investigator / Project Coordinator)
1/01/23 → 1/03/23
Project: Research
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TBRS: Multi-disciplinary Approaches to Tackle the Global Public Health Threat of Hypervirulent and Multidrug-resistant Klebsiella Pneumoniae
CHEN, S. (Principal Investigator / Project Coordinator)
1/01/23 → 25/04/23
Project: Research
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GDOTH-HK-ExtU-Lead: "環境-食品-人"重要致病菌耐藥性防控關鍵技術研究及其應用
CHEN, S. (Principal Investigator / Project Coordinator)
20/06/22 → 20/03/23
Project: Research
Prizes
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Stanford's top 2% most highly cited scientists 2022
CHEN, S. (Recipient), Nov 2022
Prize: RGC 64B - Prizes and awards
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Stanford's top 2% most highly cited scientists 2021
CHEN, S. (Recipient), Oct 2021
Prize: RGC 64B - Prizes and awards
Press/Media
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Researchers discover conjugative plasmid that augments virulence in superbug
23/10/19
3 items of Media coverage
Press/Media: Press / Media
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CityU secures research funding from the RGC to tackle the global public health threat from hypervirulent, multidrug-resistant pathogens
12/07/22
1 item of Media coverage
Press/Media: Press / Media
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CityU secures HK$43 million from RGC Theme-based Research Scheme to tackle the global public health threat from hypervirulent, multidrug-resistant pathogens
12/07/22
1 item of Media coverage
Press/Media: Press / Media
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Breakthrough in vaccine against deadly antimicrobial-resistant pathogen
27/09/21
1 item of Media coverage
Press/Media: Press / Media
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Traces the origin of an antibiotic resistance gene in the hope of blocking its transmission
26/11/20
1 item of Media coverage
Press/Media: Press / Media