Prof. CHEN Lingxi (陳凌曦)

Research Output

  1. 2024
  2. Published

    A novel deep generative model for mRNA vaccine development: Designing 5′ UTRs with N1-methyl-pseudouridine modification

    Tang, X., Huo, M., Chen, Y., Huang, H., Qin, S., Luo, J., Qin, Z., & 12 othersJiang, X., Liu, Y., Duan, X., Wang, R., Chen, L., Li, H., Fan, N., He, Z., He, X., Shen, B., Li, S. C. & Song, X., Apr 2024, In: Acta Pharmaceutica Sinica B. 14, 4, p. 1814-1826 13 p.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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  3. 2023
  4. Published

    SpecHLA enables full-resolution HLA typing from sequencing data

    Wang, S., Wang, M., Chen, L., Pan, G., Wang, Y. & Li, S. C., 25 Sept 2023, In: Cell Reports Methods. 3, 9, 100589.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 1
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  5. Published

    Heterogeneity in lung cancers by single-cell DNA sequencing

    Zhang, L., Chen, L., Li, S. C., Wang, M., Li, C., Song, T., Ni, Y., & 5 othersYang, Y., Liu, Z., Yao, M., Shen, B. & Li, W., Sept 2023, In: Clinical and Translational Medicine. 13, 9, e1388.

    Research output: Journal Publications and ReviewsLetter

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  6. Published

    Quantitative annotations of T-Cell repertoire specificity

    Luo, J., Wang, X., Zou, Y., Chen, L., Liu, W., Zhang, W. & Li, S. C., May 2023, In: Briefings in Bioinformatics. 24, 3, bbad175.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 2
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  7. Published

    Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome

    Wu, X., Wang, C. C., Cao, Y., Li, J., Li, Z., Ma, H., Gao, J., & 20 othersChang, H., Zhang, D., Cong, J., Wang, Y., Wu, Q., Han, X., Chung, P. W. J., Li, Y., Zheng, X., Chen, L., Zeng, L., Borchert, A., Kuhn, H., Chen, Z., Ng, E. H. Y., Stener-Victorin, E., Zhang, H., Legro, R. S., Mol, B. W. J. & Shi, Y., Apr 2023, In: Engineering. 23, p. 103-111

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 1
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  8. Published

    SMURF: embedding single-cell RNA-seq data with matrix factorization preserving self-consistency

    Pu, J., Wang, B., Liu, X., Chen, L. & Li, S. C., Mar 2023, In: Briefings in Bioinformatics. 24, 2, bbad026.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 2
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  9. Published

    Incorporating cell hierarchy to decipher the functional diversity of single cells

    Chen, L. & Li, S. C., 25 Jan 2023, In: Nucleic acids research. 51, 2, e9.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 3
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  10. Published

    TIMEDB: tumor immune micro-environment cell composition database with automatic analysis and interactive visualization

    Wang, X., Chen, L., Liu, W., Zhang, Y., Liu, D., Zhou, C., Shi, S., & 6 othersDong, J., Lai, Z., Zhao, B., Zhang, W., Cheng, H. & Li, S., 6 Jan 2023, In: Nucleic acids research. 51, D1, p. D1417–D1424

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 6
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  11. Published

    Deciphering complex breakage-fusion-bridge genome rearrangements with Ambigram

    Li, C., Chen, L., Pan, G., Zhang, W. & Li, S. C., 2023, In: Nature Communications. 14, 5528.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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  12. 2022
  13. Published

    A deep-learning-enabled diagnosis of ovarian cancer – Authors' reply

    Gao, Y., Li, H., Chen, L., Wu, Y., Ma, D. & Gao, Q., Sept 2022, In: The Lancet Digital Health. 4, 9, p. e631

    Research output: Journal Publications and ReviewsLetter

    Scopus citations: 1
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  14. Published

    SPROUT: spectral sparsification helps restore the spatial structure at single-cell resolution

    Wang, J., Li, S., Chen, L. & Li, S. C., Sept 2022, In: NAR Genomics and Bioinformatics. 4, 3, lqac069.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 2
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  15. Published

    Detecting TAD-like domains from RNA-associated interactions

    Zhang, Y. W., Chen, L. & Li, S. C., 26 Aug 2022, In: Nucleic Acids Research. 50, 15, e88.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 5
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  16. Published

    Deep learning-enabled pelvic ultrasound images for accurate diagnosis of ovarian cancer in China: a retrospective, multicentre, diagnostic study

    88 authors, including, 8. A. I. & Chen, L., Mar 2022, In: The Lancet Digital Health. 4, 3, p. e179-e187

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 52
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  17. Published

    PRCTC: a machine learning model for prediction of response to corticosteroid therapy in COVID-19 patients

    Gao, Y., Xiong, X., Jiao, X., Yu, Y., Chi, J., Zhang, W., Chen, L., & 2 othersLi, S. & Gao, Q., 15 Jan 2022, In: Aging. 14, 1, p. 54-72

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 1
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  18. Published

    Over-shedding of donor-derived cell-free DNA at immune-related regions into plasma of lung transplant recipient

    Luo, J., Liu, L., Chen, L., Xu, X., Wang, Y., Wei, B., Ju, C., & 16 othersWang, X., Huang, L., Zeng, W., Miao, X., Sang, L., Huang, D., Pan, G., Peng, G., Chen, Z., Zhao, Z., Yang, C., Cui, W., Jiang, W., Xu, J., Li, S. C. & He, J., Jan 2022, In: Clinical and Translational Medicine. 12, 1, e622.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 1
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  19. Published

    Somatic variant analysis suite: copy number variation clonal visualization online platform for large-scale single-cell genomics

    Chen, L., Qing, Y., Li, R., Li, C., Li, H., Feng, X. & Li, S. C., Jan 2022, In: Briefings in Bioinformatics. 23, 1, bbab452.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 7
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  20. Published

    eSMC: a statistical model to infer admixture events from individual genomics data

    Wang, Y., Zhao, Z., Miao, X., Wang, Y., Qian, X., Chen, L., Wang, C., & 1 othersLi, S., 2022, In: BMC Genomics. 23, Supplement 4, 827.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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  21. Published

    SCSilicon: a tool for synthetic single-cell DNA sequencing data generation

    Feng, X. & Chen, L., 2022, In: BMC Genomics. 23, 359.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 1
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  22. 2021
  23. Published

    SpecHap: a diploid phasing algorithm based on spectral graph theory

    YU, Y., Chen, L., Miao, X. & Li, S. C., 8 Nov 2021, In: Nucleic Acids Research. 49, 19, e114.

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 6
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  24. Published

    Prognostic implications of tumour-infiltrating lymphocytes for recurrence in epithelial ovarian cancer

    Wu, Y., Gao, Y., Chen, L., Jin, X., Chen, P. & Mo, Q., Oct 2021, In: Clinical and Experimental Immunology. 206, 1, p. 36-46

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

    Scopus citations: 2
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