Dr. LAI Kwok On (黎國安)

Research Output

  1. 2021
  2. Presented

    Arginine methylation of the RNA-binding protein G3BP1 promotes synapse development of neuron via control of actin cytoskeleton

    Lai, K. & Dong, R., 29 May 2021, (Presented).

    Research output: Conference Papers (RGC: 31A, 31B, 32, 33)33_Other conference paperpeer-review

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  3. Presented

    Arginine Methylation Outside the Nucleus: Role on Synapse Development of Neuron

    Lai, K., 23 May 2021, (Presented).

    Research output: Conference Papers (RGC: 31A, 31B, 32, 33)33_Other conference paperpeer-review

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  4. The Application of Genome-editing to Study the Pathophysiological Mechanism of Neurodegeneration and Aging in Human Induced Pluripotent Stem Cells (iPSC)

    Lyu, Q., Fan, R., Tsui, Y., Shum, D., Chan, Y. & LAI, K., 13 Mar 2021, (Presented).

    Research output: Conference Papers (RGC: 31A, 31B, 32, 33)33_Other conference paper

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  5. 2020
  6. The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation

    Lo, L. H., Dong, R., Lyu, Q. & Lai, K., Jun 2020, In: Cell Reports. 31, 10, 107744.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 8
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  7. Dysregulation of protein synthesis and dendritic spine morphogenesis in ASD: Studies in human pluripotent stem cells

    Lo, L. H. & Lai, K., 2020, In: Molecular Autism. 11, 40.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 4
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  8. Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory

    Zhao, J., Fok, A. H. K., Fan, R., Kwan, P., Chan, H., Lo, L. H., Chan, Y. & 4 others, Yung, W., Huang, J., Lai, C. S. W. & Lai, K., 2020, In: eLife. 9, e53456.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 13
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  9. The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors

    Lin, L., Lyu, Q., Kwan, P., Zhao, J., Fan, R., Chai, A., Wan Lai, C. S. & 3 others, Chan, Y., Shen, X. & Lai, K., 2020, In: PLoS Genetics. 16, 1, e1008587.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 7
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  10. 2019
  11. Application of Human-Induced Pluripotent Stem Cells (hiPSCs) to Study Synaptopathy of Neurodevelopmental Disorders

    Shen, X., Yeung, H. T. & Lai, K., Jan 2019, In: Developmental Neurobiology. 79, 1, p. 20-35

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 9
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  12. 2018
  13. Methods to Study the Signal Transduction of the Surface Receptor Tyrosine Kinase TrkB in Neurons

    Lai, K. & Ip, N. Y., 2018, The Surfaceome: Methods and Protocols. Boheler, K. R. & Gundry, R. L. (eds.). Humana Press Inc., p. 211-222 (Methods in Molecular Biology; vol. 1722).

    Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)12_Chapter in an edited book (Author)peer-review

    Scopus citations: 1
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  14. 2017
  15. Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development

    Huang, H., Lin, X., Liang, Z., Zhao, T., Du, S., Loy, M. M. T., Lai, K. & 2 others, Fu, A. K. Y. & Ip, N. Y., 15 Aug 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6992-E7001

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 9
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  16. Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A

    Lin, L., Lo, L. H., Lyu, Q. & Lai, K., Jul 2017, In: Journal of Biological Chemistry. 292, 23, p. 9451-9464

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 18
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  17. 2016
  18. Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry

    Tong, B. C., Lee, C. S., Cheng, W., Lai, K., Foskett, J. K. & Cheung, K., 6 Sep 2016, In: Science Signaling. 9, 444, ra89.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 52
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  19. Molecular Mechanisms of Dendritic Spine Development and Plasticity

    Lai, K., Jordan, B. A., Ma, X., Srivastava, D. P. & Tolias, K. F., 2016, In: Neural Plasticity. 2016, 2078121.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)Editorial Preface

    Scopus citations: 5
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  20. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines

    Liang, Z., Zhan, Y., Shen, Y., Wong, C. C., Yates III, J. R., Plattner, F., Lai, K. & 1 others, Ip, N. Y., 2016, In: Nature Communications. 7, 13282.

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 17
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  21. 2015
  22. Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development

    Liang, Z., Ye, T., Zhou, X., Lai, K., Fu, A. K. Y. & Ip, N. Y., 11 Nov 2015, In: Journal of Neuroscience. 35, 45, p. 15127-15134

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 21
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  23. Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis

    Lai, K., Liang, Z., Fei, E., Huang, H. & Ip, N. Y., 5 Jun 2015, In: Journal of Biological Chemistry. 290, 23, p. 14637-14646

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 14
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  24. Cdk5: A Key Player at Neuronal Synapse with Diverse Functions

    Lai, K. & Ip, N. Y., 2015, In: Mini-Reviews in Medicinal Chemistry. 15, 5, p. 390-395

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 15
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  25. 2013
  26. Structural plasticity of dendritic spines: The underlying mechanisms and its dysregulation in brain disorders

    Lai, K. & Ip, N. Y., Dec 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 12, p. 2257-2263

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 115
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  27. 2012
  28. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

    Lai, K., Wong, A. S. L., Cheung, M., Xu, P., Liang, Z., Lok, K., Xie, H. & 5 others, Palko, M. E., Yung, W., Tessarollo, L., Cheung, Z. H. & Ip, N. Y., Nov 2012, In: Nature Neuroscience. 15, 11, p. 1506-1515

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 113
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  29. 2011
  30. APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

    Fu, A. K. Y., Hung, K., Fu, W., Shen, C., Chen, Y., Xia, J., Lai, K. & 1 others, Ip, N. Y., Feb 2011, In: Nature Neuroscience. 14, 2, p. 181-191

    Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

    Scopus citations: 127
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