Research output per year
Research output per year
Personal profile
Author IDs
ORCID iD: 0000-0001-6430-3340
Scopus Author ID: 8631854500
Impact
Qualifications (Brief)
PhD (HKU)
Postdoc (Mayo Clinic, Rochester MN, USA)
Biography
Dr K. M. CHAN graduated with BSc and received his PhD at HKU in 2003 and 2007 respectively. He then moved to Mayo Clinic (Rochester MN, USA) for postdoctoral training and obtained the Edward C. Kendall Research Fellowship in Biochemistry before rejoining HKU as Research Assistant Professor in June 2013. In February 2015 he joined the Department of Biomedical Sciences (BMS), City University of Hong Kong as a tenure-track Assistant Professor.
Prizes/Honours
- Edward C. Kendall Research Fellowship in Biochemistry 2013, Mayo Clinic
- Professional Development Award 2015, City University of Hong Kong
Position(s) Available
We are looking for Postdoctoral Fellows, Research Assistants and Postgraduate Students to join our newly established research team. Interested candidates please send your CV and a summary of past research experience to Dr Chan: (email: [email protected])
- Applications are invited for Research Assistant I or II. Applicants with M.Phil. degree in Biological Science, Biochemistry or a related discipline; or a Bachelor's degree with at least 1 year lab work experience are welcome to apply.
- PhD positions are available. BSc or MSc students with passion in basic or applied biomedical research are encouraged to apply.
- Postdoctoral fellow positions are available upon enquiry. Please contact Dr Chan directly for further information.
Research Interests/Areas
- Epigenetics
- Chromatin Biology
- Cancer Epigenetics
- X-Chromosome inactivation
- DNA replication
Dr Chan is interested in understanding 1) how epigenetic information is maintained during cell division and 2) the role of epigenetics in regulating gene expression and human diseases. It is well known that genetic information is encoded by the DNA sequence. However, DNA alone does not account for the complexity of the mammalian genome. Chromatin, comprising DNA, core histone proteins, and other regulatory proteins, regulates gene expression and maintains genome stability. Recent studies using the next generation sequencing (NGS) technologies have identified for the first time mutations on histone genes in two pediatric brain cancers; diffuse intrinsic pontine gliomas (DIPG) and glioblastoma multiforme (GBM). Two recurrent somatic mutations (K27M and G34R/V) were identified in genes encoding the canonical histone H3.1 (HIST1H3B) and its variant H3.3 (H3F3A.) This revealed the important roles of histone modifications in human diseases and links epigenetic changes to tumorigenesis.
We are currently elucidating the functional significance of novel epigenetic protein factors in maintaining X Chromosome Inactivation as well as the roles of histone mutations in human diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis
Peng, W. (Co-first Author), Chen, S. (Co-first Author), Ma, J., Wei, W., Lin, N., Xing, J., Guo, W., Li, H., Zhang, L., Chan, K., Yen, A., Zhu, G. & Yue, J., 2025, In: Nature Communications. 16, 1917.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile3 Citations (Scopus)17 Downloads (CityUHK Scholars) -
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors
Kang, X. (Co-first Author), Li, X. (Co-first Author), Zhou, J. (Co-first Author), Zhang, Y. (Co-first Author), Qiu, L. (Co-first Author), Tian, C. (Co-first Author), Deng, Z. (Co-first Author), Liang, X., Zhang, Z., Du, S., Hu, S., Wang, N., Yue, Z., Xu, Y., Gao, Y., Dai, J., Wang, Z., Yu, C., Chen, J. & Wu, Y. & 13 others, , 28 Apr 2025, (Online published) In: Cell.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
1 Citation (Scopus) -
Hepatocellular carcinoma: signaling pathways and therapeutic advances
Zheng, J., Wang, S., Xia, L., Sun, Z., Chan, K. M., Bernards, R., Qin, W., Chen, J., Xia, Q. & Jin, H., 2025, In: Signal Transduction and Targeted Therapy. 10, 35.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile21 Citations (Scopus)34 Downloads (CityUHK Scholars) -
Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis
Guo, X., Asthana, P., Zhai, L., Cheng, K. W., Gurung, S., Huang, J., Wu, J., Zhang, Y., Mahato, A. K., Saarma, M., Ustav, M., Kwan, H. Y., Lyu, A., Chan, K. M., Xu, P., Bian, Z.-X. & Wong, H. L. X., 2024, In: Nature Communications. 15, 1034.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile14 Citations (Scopus)41 Downloads (CityUHK Scholars) -
DNA polymerase delta governs parental histone transfer to DNA replication lagging strand
Tian, C. (Co-first Author), Zhang, Q. (Co-first Author), Jia, J. (Co-first Author), Zhou, J. (Co-first Author), Zhang, Z. (Co-first Author), Karri, S., Jiang, J., Dickinson, Q., Yao, Y., Tang, X., Huang, Y., Guo, T., He, Z., Liu, Z., Gao, Y., Yang, X., Wu, Y., Chan, K. M., Zhang, D. & Han, J. & 2 others, , 14 May 2024, In: Proceedings of the National Academy of Sciences. 121, 20, e2400610121.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile11 Citations (Scopus)27 Downloads (CityUHK Scholars)
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RIF-ExtU-Lead: Development of Liquid Biopsy Assays based on Exosomal Small Non-Coding RNAs for Non-Invasive Early Detection of Pancreatic Cancer
WANG, X. (Main Project Coordinator [External]) & CHAN, K. M. (Principal Investigator / Project Coordinator)
30/06/24 → …
Project: Research
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GRF: Investigate the Mechanism of H2BG53D Mutation in Pancreatic Ductal Adenocarcinoma
CHAN, K. M. (Principal Investigator / Project Coordinator)
1/09/23 → …
Project: Research
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TDG(CityU): Using a Course-based Undergraduate Research Experiences (CURE) Model to Enhance the Research Interest of Health Professional and Biomedical Science Students
CHAN, K. M. (Principal Investigator / Project Coordinator)
1/12/22 → …
Project: Research
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NSFC-GP-SRI: 组蛋白H2BE113K突变影响核小体酸性口袋功能驱动乳腺癌发生发展的机制研究
CHAN, K. M. (Principal Investigator / Project Coordinator)
1/01/22 → …
Project: Research
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OTHERS-SRI: 肿瘤相关组蛋白突变H2BG53D、E76K及E113K的相互作用蛋白及致癌分子机制研究
CHAN, K. M. (Principal Investigator / Project Coordinator)
1/01/22 → …
Project: Research
Press/Media
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Uncovering the secret of RNA paves the way for drug discovery for Covid-19
YAN, J., ZHANG, L., CHAN, K. M., LI, J. & ZHU, X.
10/08/20
1 item of Media coverage
Press/Media: Press / Media
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CityU’s CRISPR-assisted novel method detects RNA-binding proteins in living cells
YAN, J., ZHANG, L., CHAN, K. M. & ZHU, X.
9/07/20
1 item of Media coverage
Press/Media: Press / Media
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CityU biologists discover super-enhancers that switch on breast cancer genes
HU, J., CHIN, R. Y. M., WANG, X., CHAN, K. M. & ZHANG, L.
15/04/21
1 item of Media coverage
Press/Media: Press / Media