Prof. Jufang HE, 賀菊方

Projects

Projects per year 2010 2019 2020 2025

• 22 Active
• 26 Finished

Projects per year

Search results

• Active

  CRF: Long-term Rescuing Effects on Remembering and Memory Retention in Alzheimer’s Disease Mice with Self-synthesized CCK-B Receptor Agonists

  HE, J. (Principal Investigator / Project Coordinator), CHEN, X. (Co-Principal Investigator), LAI, S. W. C. (Co-Principal Investigator), LI, Y. (Co-Principal Investigator), TORTORELLA, M. D. (Co-Principal Investigator) & YANG, S. (Co-Principal Investigator)

  30/06/25 → …

  Project: Research

• GRF: Roles of Cholecystokinin in The Plasticity of Gabaergic and Glutamatergic Synapses in The Basolateral Amygdala

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/25 → …

  Project: Research

  • Cholecystokinin 100%
  • Basolateral Amygdala 75%
  • Synapse 50%
  • Glutamatergic 50%
  • GABAergic 50%

• GRF: Cholecystokinin from the Thalamocortical Projection Facilitates Heterosynaptic Visual Inputs in the Auditory Cortex and Visuoauditory Association

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/24 → …

  Project: Research

  • Cholecystokinin 100%
  • Long-Term Potentiation 42%
  • Behavior (Neuroscience) 30%
  • Basolateral Amygdala 28%
  • Auditory Cortex 28%

• SRFS: The Medial Prefrontal Cortex Facilitates Learning and Memory in the Auditory Cortex Through the Medial Temporal Lobe

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/24 → …

  Project: Research

  • Cholecystokinin 100%
  • Behavior (Neuroscience) 54%
  • Basolateral Amygdala 50%
  • GABA Receptor 29%
  • Interneuron 25%

• CRF-ExtU-Lead: Sonogenetics for Specific Deep Neural Circuit Modulation and Mitigation of Parkinsonian Mice

  SUN, L. (Main Project Coordinator [External]) & HE, J. (Principal Investigator / Project Coordinator)

  1/06/23 → …

  Project: Research

• ResCtrs: Research Centre for Treatments of Brain Disorders (CBD) (provisional status)

  HE, J. (Principal Investigator / Project Coordinator), KUO, T.-W. (Principal Investigator / Project Coordinator), CHAN, W. Y. K. (Co-Investigator), CHAN, L. H. L. (Co-Investigator), CHEN, X. (Co-Investigator), LAU, C. Y. G. (Co-Investigator), LEE, Y. (Co-Investigator), SHI, P. (Co-Investigator), SUN, H. (Co-Investigator) & YANG, S. (Co-Investigator)

  17/03/23 → …

  Project: Research

• GRF: Heterosynaptic Neuroplasticity of the Ascending Inputs in the Auditory Thalamus by Corticothalamic Modulation

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/23 → …

  Project: Research

  • Cholecystokinin 100%
  • Neuroplasticity 56%
  • Long-Term Potentiation 52%
  • Hippocampus 35%
  • Behavior (Neuroscience) 30%

• HMRF: CCK-B Receptor Antagonist for the Treatment of Depression in the Mouse Model

  HE, J. (Principal Investigator / Project Coordinator) & CHEN, X. (Co-Investigator)

  1/11/22 → …

  Project: Research

  • Cholecystokinin 100%
  • Long-Term Potentiation 46%
  • Basolateral Amygdala 27%
  • Hippocampus 23%
  • Neuroplasticity 23%

• CRF: Synthesized CCK-B Receptor Agonists to Alleviate Anterograde Amnesia in Animal Models

  HE, J. (Principal Investigator / Project Coordinator), Chan, Y.-S. (Co-Principal Investigator), LI, Y. (Co-Principal Investigator), TORTORELLA, M. D. (Co-Principal Investigator) & YANG, S. (Co-Principal Investigator)

  30/06/22 → …

  Project: Research

  • Cholecystokinin 100%
  • Hippocampus 37%
  • Long-Term Potentiation 32%
  • Behavior (Neuroscience) 32%
  • Neuroplasticity 31%

• GRF: Gene Therapy for Epilepsy through Enhancing Inhibition with High-Frequency Activation of GABAergic Neurons in Mice

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/22 → …

  Project: Research

  • Cholecystokinin 100%
  • Long-Term Potentiation 41%
  • Neuroplasticity 37%
  • GABA Receptor 26%
  • Hippocampus 25%

• HMRF: Cholecystokinin Receptor Agonists as Potential New Drugs for Rescuing Learning and Memory Deficiency in Aged Wild Type and Alzheimer’s Disease Animals

  LI, X. (Principal Investigator / Project Coordinator) & HE, J. (Co-Investigator)

  1/12/21 → …

  Project: Research

  • Cholecystokinin 100%
  • Long-Term Potentiation 43%
  • Behavior (Neuroscience) 41%
  • Basolateral Amygdala 38%
  • Neuroplasticity 27%

• ITF-InnoHK-ExtU-Lead: In-Vitro and In-Vivo Assay Platforms for Assessing Drug Efficacy for Brain Disorders

  HE, J. (Principal Investigator / Project Coordinator), LEE, Y. (Co-Investigator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• ITF-InnoHK-ExtU-Lead: Preserving the Brain Extracellular Matrix Using Small Molecule Drugs as a Strategy for Blocking Neural Degeneration

  HE, J. (Principal Investigator / Project Coordinator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• ITF-InnoHK-ExtU-Lead: FSH Lead Antibodies Identification and Selection for Process Development

  HE, J. (Principal Investigator / Project Coordinator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• ITF-InnoHK-ExtU-Lead: Development of Antagonists for Alleviating Epilepsy

  HE, J. (Principal Investigator / Project Coordinator), LAU, C. Y. G. (Co-Investigator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• ITF-InnoHK-ExtU-Lead: Mechanism-Based Studies on the Role of CCKBR in Brain Health

  HE, J. (Principal Investigator / Project Coordinator), LAU, C. Y. G. (Co-Investigator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• ITF-InnoHK-ExtU-Lead: Development of CCK Agonists as a Stratagem for Curing Tinnitus

  HE, J. (Principal Investigator / Project Coordinator), SUN, H. (Co-Investigator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• ITF-InnoHK-ExtU-Lead: FSH Antibody Design and Production

  HE, J. (Principal Investigator / Project Coordinator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• ITF-InnoHK-ExtU-Lead: FSH Antibody Screen and Selection for Biology and Pharmacology Studies in Animal Models of Diseases

  HE, J. (Principal Investigator / Project Coordinator) & TORTORELLA, M. D. (Co-Investigator)

  5/09/20 → …

  Project: Research

• OTHERS-SRI: 一种光敏感性癫痫小鼠模型的建立与验证

  HE, J. (Principal Investigator / Project Coordinator), 刘雪 (Co-Investigator) & 王枫 (Co-Investigator)

  1/01/20 → …

  Project: Research

• TBRS-ExtU-Lead: A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases

  IP, N.Y.-Y. (Main Project Coordinator [External]) & HE, J. (Principal Investigator / Project Coordinator)

  1/01/19 → …

  Project: Research

  • Behavior (Neuroscience) 100%
  • Cholecystokinin 76%
  • Auditory Cortex 61%
  • Anterior Cingulate Cortex 38%
  • Neuronal Activity 38%

• ASDC: Center for Advanced Nuclear Safety and Sustainable Development (ANSD)

  KAI, J.-J. (Principal Investigator / Project Coordinator), FAN, J. (Co-Investigator), HE, J. (Co-Investigator), HU, A. (Co-Investigator), LAU, C. (Co-Investigator), WANG, Z. (Co-Investigator), WOO, C. H. (Co-Investigator), XIE, M. (Co-Investigator), ZHANG, K. (Co-Investigator), ZHAO, J. (Co-Investigator) & ZHOU, W. (Co-Investigator)

  16/02/16 → …

  Project: Research

  • Stainless Steel 100%
  • High Entropy Alloys 91%
  • Yield Stress 66%
  • Work Hardening 54%
  • Density 51%
• Finished

  ITF: Platform Development for New Anti-epileptic Drug Evaluation and Pre-clinical Study of New Cholecystokinin Antagonists as New Anti-epileptic Drugs

  HE, J. (Principal Investigator / Project Coordinator), LI, X. (Co-Investigator) & Tu, Z. (Co-Investigator)

  1/06/21 → 31/05/23

  Project: Research

  • Preclinical Study 100%
  • Drug Screening 100%
  • Cholecystokinin Receptor Blocking Agent 100%
  • Anticonvulsive Agent 100%
  • Cholecystokinin 50%

• GRF: A Novel CCK Receptor Regulates the Long-term Potentiation of Inhibition in the Auditory Cortex

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/21 → 16/12/24

  Project: Research

  • Cholecystokinin 100%
  • Long-Term Potentiation 58%
  • Auditory Cortex 47%
  • Neuroplasticity 44%
  • Long Term Potentiation 33%

• GDOTH-HK: 探索源自内嗅皮层的胆囊收缩素对于新皮层跨模态联合学习的关键性调节作用 

  SUN, W. (Principal Investigator / Project Coordinator) & HE, J. (Co-Investigator)

  1/12/19 → 24/06/22

  Project: Research

• GDOTH-HK: 源于内嗅皮层的胆囊收缩素对于新皮层癫痫的促发作用 

  LI, X. (Principal Investigator / Project Coordinator) & HE, J. (Co-Investigator)

  1/12/19 → 24/06/22

  Project: Research

• ITF: CCK-B Receptor Antagonists For The Treatment Of Depression Especially Chronic Pain Comorbid Depression Of Elderly 

  HE, J. (Principal Investigator / Project Coordinator), MA, C. H. E. (Co-Investigator), RONG, J.-H. (Co-Investigator) & ZHAO, J. (Co-Investigator)

  1/07/19 → 31/08/22

  Project: Research

  • Cholecystokinin 100%
  • Cholecystokinin B Receptor 47%
  • Receptor Antagonist 43%
  • Treatment of Depression 43%
  • Cholecystokinin B Receptor Antagonist 43%

• HMRF: Neuroplasticity Induced by the Administration of Cholecystokinin Tetrapeptide and Noise Exposure as a Novel Strategy for the Treatment of Tinnitus

  CHEN, X. (Principal Investigator / Project Coordinator), HE, J. (Co-Investigator) & YANG, S. (Co-Investigator)

  1/05/19 → 24/04/24

  Project: Research

  • Cholecystokinin 100%
  • Long-Term Potentiation 57%
  • Entorhinal Cortex 42%
  • Auditory Cortex 42%
  • Neuroplasticity 34%

• HMRF: The Development of Upconversion-based Wireless Optogenetics as an All-optical Therapeutic Strategy to Study and Treat Parkinson's Disease

  SHI, P. (Principal Investigator / Project Coordinator), HE, J. (Co-Investigator) & Yung, W. H. (Co-Investigator)

  1/05/19 → 28/07/23

  Project: Research

  • In Vivo 100%
  • MicroRNA 90%
  • Dynamics 66%
  • Methylation 37%
  • Induced Pluripotent Stem Cell 30%

• GRF: Cholecystokinin Administration Rescues Thalamocortical Neuroplasticity in Old Rodents

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/19 → 13/12/22

  Project: Research

  • Cholecystokinin 100%
  • Neuroplasticity 54%
  • Auditory Cortex 48%
  • Long-Term Potentiation 45%
  • Synapse 35%

• ITF: Assay Platforms for CCK-B Receptor Agonists as Potential Treatment for Amnestic Mild Cognitive Impairment

  HE, J. (Principal Investigator / Project Coordinator), CHEN, X. (Co-Investigator), Guo, Y. (Co-Investigator), HOKFELT, T. (Co-Investigator), LAI, K.-O. (Co-Investigator), LAU, C. Y. G. (Co-Investigator), LEE, Y. (Co-Investigator), LI, X. (Co-Investigator), SUN, H. (Co-Investigator), TORTORELLA, M. D. (Co-Investigator) & ZHU, G. (Co-Investigator)

  1/03/18 → 28/02/21

  Project: Research

  • Cholecystokinin 100%
  • Auditory Cortex 80%
  • Behavior (Neuroscience) 80%
  • Long-Term Potentiation 49%
  • Neuroplasticity 38%

• GRF: GABAergic Cholecystokinin Enhances the Local Inhibitory Effect in the Auditory Cortex

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/18 → 30/12/21

  Project: Research

  • Cholecystokinin 100%
  • Auditory Cortex 80%
  • Behavior (Neuroscience) 45%
  • Synapse 31%
  • Long-Term Potentiation 27%

• GRF: Cortical Cholecystokinin as a Chemical Switch Enabling Auditory Long-term Potentiation in the Thalamus

  HE, J. (Principal Investigator / Project Coordinator) & YANG, S. (Co-Investigator)

  1/01/17 → 29/12/20

  Project: Research

  • Cholecystokinin 100%
  • Long-Term Potentiation 75%
  • Thalamus 75%
  • Auditory Cortex 66%
  • Associative Memory 50%

• NSFC-SRI: 源于内嗅皮层的胆囊收缩素在皮层长时程增强中的功能及在学习记忆中的作用

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/17 → 31/12/20

  Project: Research

• CRF: Neuronal Mechanism of Cholecystokinin-Facilitated Cross-modal Learning and Memory

  HE, J. (Principal Investigator / Project Coordinator), SHI, P. (Co-Principal Investigator), Chan, Y.-S. (Co-Investigator) & SHUM, D. K. Y. (Co-Investigator)

  1/06/16 → 29/05/20

  Project: Research

  • Long-Term Potentiation 100%
  • Cholecystokinin 92%
  • Auditory Cortex 74%
  • Brain Areas 47%
  • Temporal Lobe Epilepsy 41%

• HMRF: Local Infusion of Cholecystokinin in the Auditory Cortex and Successive Sound Stimuli Lead to Epileptic Seizures

  HE, J. (Principal Investigator / Project Coordinator), HU, B. (Co-Investigator) & LI, X. (Co-Investigator)

  1/06/16 → 12/12/19

  Project: Research

  • Auditory Cortex 100%
  • Cholecystokinin 69%
  • Long-Term Potentiation 55%
  • Associative Memory 55%
  • Behavior (Neuroscience) 33%

• GRF: How Activation of the Auditory Thalamus Induces Neuronal Plasticity in the Auditory Cortex?

  HE, J. (Principal Investigator / Project Coordinator) & Guo, Y. (Co-Investigator)

  1/01/16 → 19/12/19

  Project: Research

  • Cholecystokinin 100%
  • Auditory Cortex 66%
  • Long-Term Potentiation 48%
  • Thalamus 34%
  • Neuronal Plasticity 34%

• HMRF: Rewiring the De-afferented Thalamic and Cortical Neurons to the Remaining Auditory Inputs: A Model for Treatment of Tinnitus Patients

  HE, J. (Principal Investigator / Project Coordinator) & Guo, Y. (Co-Investigator)

  1/06/14 → 1/12/17

  Project: Research

  • Cholecystokinin 100%
  • Associative Memory 100%
  • Auditory Cortex 80%
  • Behavior (Neuroscience) 60%
  • Electrotherapy 20%

• DON: How Brain Encodes Memory

  HE, J. (Principal Investigator / Project Coordinator)

  1/05/14 → 28/12/20

  Project: Research

  • brain 100%

• GRF: Participation of the Thalamus in the Establishment of Cross-modal Association between the Auditory and Visual Systems

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/14 → 27/12/17

  Project: Research

  • Auditory Cortex 100%
  • Auditory System 100%
  • Thalamus 100%
  • Visual Cortex 66%
  • Cholecystokinin 66%

• NSFC-SRI: 听觉和视觉系统在皮层下和皮层水平的交互作用

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/14 → 31/12/17

  Project: Research

• GRF: Accumulative Effect of Stimulus-Specific Adaptation through the Ascending Pathway to the Auditory Cortex

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/13 → 29/12/16

  Project: Research

  • Thalamus 100%
  • Auditory Cortex 100%
  • Membrane Potential 50%
  • Cerebral Cortex 50%

• MOST-SRI: 突触蛋白功能异常在老年痴呆症发病过程中的作用（后三年）

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/13 → 31/08/17

  Project: Research

• TBRS-ExtU-Lead: Stem Cell Strategy for Nervous System Disorders

  IP, N.Y.-Y. (Main Project Coordinator [External]) & HE, J. (Principal Investigator / Project Coordinator)

  1/01/13 → 12/01/18

  Project: Research

• MOST-SRI: 突触蛋白功能异常在老年痴呆症发病过程中的作用（前两年）

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/13 → 31/08/17

  Project: Research

• GRF: The Interaction of Stimulus-specific Adaptation between the Thalamic Reticular Nucleus and Medial Geniculate Body

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/12 → 11/12/15

  Project: Research

  • Thalamic Reticular Nucleus 100%
  • Thalamus 100%
  • Innervation 66%
  • Membrane Potential 16%
  • Cerebral Cortex 16%

• GRF: Corticofugal Modulation of Deviance Stimulus Detection in the Thalamic Reticular Nucleus

  HE, J. (Principal Investigator / Project Coordinator)

  1/01/11 → 29/09/14

  Project: Research

  • Thalamic Reticular Nucleus 100%
  • Thalamus 100%
  • Excitability 20%
  • Auditory Cortex 20%
  • Oddball Paradigm 20%

• CRF: The Brain Mechanisms to Use Electronic "Bat Ears" to Replace Vision: From Human to Animal Users

  HE, J. (Principal Investigator / Project Coordinator)

  1/06/10 → 27/08/14

  Project: Research