Prof. YIN Huiyong (尹慧勇)

Professor Huiyong YIN is currently the tenured Professor of Biomedical Sciences in Metabolism and Metabolic Diseases in the Department of Biomedical Sciences. Before joining City University of Hong Kong in February 2023, Prof. Yin was the Senior Principal Investigator (Professor Level II，中科院特聘研究员，二级教授) and Group Leader of Lipid Metabolism in Human Nutrition-related Diseases at Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), Shanghai, China. He was also the Distinguished Adjunct Professor in the School of Life Sciences and Technology in ShanghaiTech University since 2013. He obtained his BSc from Tongji University and MSc from Shanghai Institute of Organic Chemistry (SIOC), CAS, and PhD in Chemistry from Vanderbilt University in 2002. In 2003, Prof. Yin joined Vanderbilt University School of Medicine as a Research Instructor in the Division of Clinical Pharmacology, and was promoted to a Research Assistant Professor in 2005 and Associate Professor in 2008 in the Departments of Pharmacology, Medicine, and Chemistry. He also served as the Director for the Core Laboratory of Drug Metabolism and Pharmacokinetics (DMPK) in the drug discovery program at Vanderbilt University from 2007-2009. In August 2011, Prof. YIN was recruited back to the Institute of Nutritional Sciences (INS), Shanghai Institutes of Biological Sciences (SIBS), CAS, under the global talent recruitment program by Shanghai Municipal Government and CAS. He was the founding director of the Mass Spectrometry Facility for Nutrition and Food Safety at INS, SIBS from 2011 to 2017.

Professor Yin is one of the leading scientists in the field of redox regulation of glucose and lipid metabolism in human metabolic diseases. His research interest has been focusing on the understanding of metabolic reprogramming in carbohydrate and lipid metabolism in metabolic diseases including atherosclerosis, liver cancer, hyperuricemia and gout. For the past 20 years, Prof. Yin has made significant contributions in understanding the roles and underlying mechanisms of free radical lipid peroxidation in human diseases including atherosclerosis using the state-of-the art metabolomics/lipidomics approaches (Yin et al JACS, 2000; 2002; Yin et al Chem. Rev. 2011; Zhong et al, Redox Biol. 2015; Zhong et al, Free Radic. Biol. Med. 2019), and discovered the novel non-enzymatic functions of Aldehyde Dehydrogenase 2 (ALDH2) in cardiovascular disease (CVD) (Zhong et al, J. Clin. Invest. 2019; Li et al, JCI Insight, 2021; Zhong et al, Redox Biol. 2021; Zhang et al, Nat. Rev. Cardiol. 2023). His research for the past five years has defined the pathways in metabolic reprogramming in liver cancer mediated by a key glycolytic enzyme fructose-1,6-bisphosphate aldolase B (ALDOB) (Li et al, Nature Cancer, 2020; He et al, PLoS Biol., 2020; Liu et al, Hepatology, 2021). Using a precision medicine approach based on metabolomics and machine learning algorithms, Prof. Yin and his collaborators have established prediction models in assessing risks for gout attacks in asymptomatic hyperuricemia patients and the frequencies for gout flares (Shen et al, Arthritis. Rheumatol., 2021; Lu et al, Nat. Rev. Rheumatol., 2019). Since 2000, Prof. Yin has co-authored around 160 peer-reviewed manuscripts in SCI-indexed journals including Science, Nature, Cell Metabolism, Nature Cancer, Nature Metabolism, Nature Review Cardiology, Nature Reviews Rheumatology, Molecular Cell, Journal of American Chemical Society, Hepatology, Redox Biology, Arthritis & Rheumatology, Free Radical Biology and Medicine, Journal of Biological Chemistry, Journal of Clinical Endocrinology and Metabolism, and Journal of American Society for Mass Spectrometry with > 11,700 Google Scholar citations and h-index of 60 (as of April 2023).  Prof. Yin has been listed as the top 2% of the Most-Cited Scientists by Stanford University since 2021 and was awarded prestigious “Senior International Scientists” in 2021 by National Natural Science Fund of China.

Professor Yin received “Pollyanna Chu Yuet Wah Outstanding Mentor Award” of Chinese Academy of Sciences（中国科学院朱李月华优秀教师奖） in 2022; “Senior International Scientist” （外国资深研究学者）by NSF-China in 2021; “Outstanding Mentor Award” from ShanghaiTech University in 2020; CAS BR (2011) and “Shanghai Expert” (上海特聘专家“) by Shanghai Municipal Government in 2012; Travel Award from Society for Free Radical Biology and Medicine (SFRBM) in 2004 and Young Investigator Award in 2005; Best Research Paper from Vanderbilt School of Medicine 2006; Warren Fellowship from Department of Chemistry at Vanderbilt University in 2000; CAS President Award for outstanding graduate student in 1995.

Research interests in keywords:

Metabolic reprogramming; metabolomics/lipidomics; atherosclerosis; liver cancer; lipid peroxidation; hyperuricemia and gout; mass spectrometry; ALDH2; Aldolase

• Redox regulation of lipid and carbohydrate metabolism: lipid peroxidation, Reactive Oxygen Species (ROS), and ferroptosis
• Metabolic homeostasis and tissue cross-talks
• Metabolic reprogramming in tissue microenvironment
• Immunometabolism in atherosclerosis and myocardial infarction
• Metabolic interplays of cancer cells and immune cells
• Nutrient sensing and metabolic pathways in metabolic diseases
• Disease biomarker discovery using multi-omics integration, including metabolomics/lipidomomics, proteomics, transcriptomics, and single cell analysis , in combination with machine learning algorithms

RECENT EXTERNAL COMPETITIVE GRANTS (since 2012)

• Natural Science Foundation of China (NSFC), Categorized Key Projects (2023-2025，中国自然科学基金委专项) , ”Fructose uptake and metabolic homeostasis”, 2,500,000 RMB, No. 32241017, PI
• Natural Science Foundation of China (NSFC), Research Fund for Senior International Scientists (2022-2023，中国自然科学基金委外国资深研究学者）, ”Physiological and pathophysiological basis for enzymatic plasticity”, 1,600,000 RMB, No. 32150710522, PI
• Natural Science Foundation of China (NSFC), Key Research Project (2021-2025， 中国自然科学基金委重点项目) , ”Mitochondrial ALDH2 in cholesterol metabolism”, 3,450,000 RMB, No. 32030053, PI
• Ministry of Science and Technology of China (MOST), Key Research Project (2022-2025), ”Early detection, phenotyping and precision treatment of inflammatory arthritis”, 1,050,000 RMB, No. 2022YFC2503300, Co-I（Group Member）
• Ministry of Science and Technology of China (MOST), Key Research Project (2019-2024), ”Detection and functional studies of novel metabolites during major organ development”, 860,000 RMB, No. 2022YFC2503300, Co-I
• Shanghai Municipal Science and Technology Commission, Animal Model Project (2022-2025), ”Diabetic mouse model based on beta cell-specific ALDOB KO and R46A mutant”, 250,000 RMB, No. 22140903300, PI
• Natural Science Foundation of China (NSFC), Major Research Program on Spatiotemporal Regulation of Metabolism (2019-2021), ”Spatiotemporal control of lipid metabolism by ALDH2 in Atherosclerosis”, 850,000 RMB, No. 91857112, PI
• Ministry of Science and Technology of China (MOST), Key Research Project (2016-2020), ”Quality control and composition analysis during food processing”, 1,500,000 RMB, No. 2016YFD0400205, Co-I
• Natural Science Foundation of China (NSFC), General Research Project (2017-2020) , ”Fructose-1,6-bisphosphate aldolase in metabolic reprogramming of hepatocellular carcinoma”, 610,000 RMB, No. 31671231, PI
• Natural Science Foundation of China (NSFC), General Research Project (2015-2018) , ”Characterisation and functional study of a novel oxidized phospholipids in LDL in atherosclerosis”, 850,000 RMB, No. 31470831, PI
• Ministry of Science and Technology of China (MOST), China Precision Medicine Initiative (2016-2018), ”Precision medicine approach to study gout using proteomics and metabolomics”, 1,000,000 RMB, No. 2016YFC0903403, Co-PI
• Ministry of Science and Technology of China (MOST), Key Research Project (2012-2016), ”Biomarkers in non-alcoholic fatty liver disease”, 1,280,000 RMB, No. 2012CB524905, Co-I
• Natural Science Foundation of China (NSFC), Major Research Program on Vascular homeostasis and remodelling (2015-2017), ”Tipping point and regulatory networks during the progression of atherosclerosis”, 750,000 RMB, No. 91439103, Co-PI
• Natural Science Foundation of China (NSFC), General Research Project (2012-2015) , ”Mitochondrial cardiolipin oxidation in apoptosis”, 600,000 RMB, No. 31170809, PI

ACADEMIC PROFILES:

• Secretary General, Asian Pacific Gout Consortium (APGC), (2018 - )
• Managing Committee Member, HNE Club associated with the Society for Free Radical Research International (SFRRI) (2010 - )
• Vice president and Secretary General, Chinese Society for Free Radical Biology and Medicine, Biophysical Society of China, (2020 - )
• Deputy Secretary General and Council Member, Chinese Society for Metabolomics, Biophysical Society of China, (2019 - )
• Secretary General, Chinese Society for Hyperuricemia and Gout, China Society of Geriatrics, (2018 - )
• Council Member, Chinese Society for Metabolic Biology, Biophysical Society of China, (2019 - )
• Council member of Sub-committee of Atherosclerosis, Chinese Association of Pathophysiology (2016 - )
• Council member of China Society of Geriatrics (2018 - )

In addition to serving as an editor for Free Radical Biology and Medicine, Professor Yin is also on the editorial boards for six international journals in the field of redox biology, metabolism, and medicine. He also routinely reviews manuscripts for high impact journals in the field of metabolism, including Nature Metabolism, Cell Metabolism, Life Metabolism, Nature Communications, Nature Chemical Biology, among others.

Editor for Free Radical Biology and Medicine

https://www.sciencedirect.com/journal/free-radical-biology-and-medicine/about/editorial-board

Editorial Board member:

1. Redox Biology
   https://www.journals.elsevier.com/redox-biology%20/editorial-board
2. Redox Biochemistry and Chemistry
   https://www.sciencedirect.com/journal/redox-biochemistry-and-chemistry/about/editorial-board
3. Redox Experimental Medicine
   https://rem.bioscientifica.com/page/edboard/
4. Global Translational Medicine
   https://accscience.com/journal/GTM/about/editorial_board
5. Gout, Urate, and Crystal Deposition Disease
   https://www.mdpi.com/journal/gucdd/editors
6. Journal of Integrative Agriculture
   https://www.journals.elsevier.com/journal-of-integrative-agriculture/editorial-board/hui-yong-yin