Prof. ZHU Guangyu (朱光宇)

Dr. Guangyu Zhu obtained his B.Sc. in Chemistry from Peking University (2002) under the guidance of Prof. LAI Luhua, where he developed a strong passion for biological chemistry and drug discovery. He moved to the United States and obtained a Ph.D. in Biological Chemistry from the University of Pittsburgh (2007) with Prof. Billy W. Day, where he was working on anticancer drug development and discovery. He subsequently did his postdoc at Massachusetts Institute of Technology (MIT) with Prof. Stephen J. Lippard working on the mechanism of action of cisplatin, one of the most widely used chemotherapeutic drugs in the clinic. He joined the City University of Hong Kong as an Assistant Professor in 2011. Dr. Zhu's research interest lies at the interface of chemistry and biology, in the study of the mechanisms of anticancer drugs especially DNA-damaging agents and the development of innovative anticancer agents. His future research will focus on DNA damage response and repair pathways, transcription inhibition, and DNA-protein interaction, by using interdisciplinary approaches and methods in the areas of biological chemistry, biochemistry, molecular biology, and chemical biology.

• DNA damage and repair
• Anticancer drug mechanism and development
• Chemical biology

BCH2005_2005A Principles of Environmental Chemistry

• Basic concepts
• Natural waters (hydrosphere)
• Minerals, clay, soil, and sediments (lithosphere)
• Biochemistry of important elements (biosphere)

BCH2071_2071A Biological Chemistry

• Structure and property of nucleic acids

• Structure and property of carbohydrates

BCH4045 Medicinal Chemistry

• Drug discovery, design, and development process

• Drug target and drug

• Drug metabolism

• Prodrugs and drug delivery systems

• Combinatorial chemistry, antisense, proteomics, comparative and functional genomics, pharmacogenomics, bioinformatics, high-throughput screening, Chinese medicine

BCH6112 Environmental Analysis

• Introduction to environmental analysis

• Colorimetric methods and FIA

• Metal analysis with AAS, ICP-MS, and XRF