Research output per year
Research output per year
Research output
- 1 - 50 out of 93 results
Search results
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2025
A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo
Liew, S. W., Cao, D., Petersen, R. J., Butcher, S. E., Kennedy, S. G. & Kwok, C. K., 24 Mar 2025, In: Nucleic Acids Research. 53, 5, gkaf137.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile3 Downloads (CityUHK Scholars) -
Enhanced Detection of Enrofloxacin in Seawater Using a Newly Selected Aptamer on a Graphite Oxide-Based Biosensor
Lam, S. Y. (Co-first Author), Li, P. (Co-first Author), Jin, L., Chan, H. Y., Ruan, Y., Kwok, C. K. & Lo, P. K., 1 Apr 2025, In: Analytical Chemistry. 97, 12, p. 6735-6744Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Enhanced Detection Of Enrofloxacin In Seawater Using A Newly Selected Aptamer On A Graphite Oxide-Based Biosensor
KWOK, C. K. (Inventor), LO, P. K. P. (Inventor), LAM, S. Y. (Inventor) & LI, P. (Inventor), 10 Apr 2025, (Accepted/In press/Filed) Priority No. 63/786,928Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Pre-Defined Stem-Loop Structure Library for the Discovery of L-RNA Aptamers that Target RNA G-Quadruplexes
Ji, D., Wang, B., Lo, K. W., Tsang, C. M. & Kwok, C. K., 27 Jan 2025, In: Angewandte Chemie International Edition. 64, 5, e202417247.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
1 Citation (Scopus) -
Rapid and sensitive one-pot CRISPR/Cas12a-based detection of enteroaggregative Escherichia coli
LIM, C. K. (Inventor), LIEW, S. W. (Inventor), KWOK, C. K. (Inventor) & LEE, P. K. H. (Inventor), 14 Feb 2025, (Accepted/In press/Filed) Priority No. 63/758,868Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells
Zhang, K. (Co-first Author), Nie, Q. (Co-first Author), Li, M. (Co-first Author), Chen, X., Zhong, L., Dai, T., Guo, X., Zhao, H., Lau, T.C.-K., Wang, H., Chen, S.-B. & Kwok, C. K., 10 Feb 2025, In: Nucleic Acids Research. 53, 3, gkaf039.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile10 Downloads (CityUHK Scholars) -
2024
Aptamer-Peptide Conjugates
KWOK, C. K. (Inventor) & ZHANG, K. (Inventor), 1 Mar 2024, (Accepted/In press/Filed) Priority No. 18/593,510Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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A selective HIV-1 RNA G-quadruplex-targeting L-aptamer–D-antisense conjugate inhibits HIV-1 minus strand transfer
Feng, H. & Kwok, C. K., 28 Nov 2024, In: Chemical Communications. 60, 92, p. 13558-13561Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
1 Citation (Scopus) -
Capture of RNA G-quadruplex structures using an L-RNA aptamer
Lam, S. Y., Umar, M. I., Zhao, H., Zhao, J. & Kwok, C. K., 1 Oct 2024, In: RSC Chemical Biology. 5, 10, p. 1045-1051Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile1 Citation (Scopus)17 Downloads (CityUHK Scholars) -
Conjugates, And Uses Thereof
KWOK, C. K. (Inventor) & ZHANG, K. (Inventor), 28 Nov 2024, (Accepted/In press/Filed) Priority No. 18/963,702Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1
Zhang, Y., Zhao, J., Chen, X., Qiao, Y., Kang, J., Guo, X., Yang, F., Lyu, K., Ding, Y., Zhao, Y., Sun, H., Kwok, C. K. & Wang, H., 15 Nov 2024, In: Nature Communications. 15, 19 p., 9890.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile1 Citation (Scopus)11 Downloads (CityUHK Scholars) -
G4-Specific Peptides And Methods Of Identifying The Same
KWOK, C. K. (Inventor) & MOU, X. (Inventor), 30 Jan 2024, (Accepted/In press/Filed) Priority No. 18/427,626Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Hook-Like DNAzyme-Activated Autocatalytic Biosensor for the Universal Detection of Pathogenic Bacteria
Liu, Y., Shi, Y., Wang, S., Liu, S., Shang, M., Zhao, B., Liu, H., Yang, C., Wang, F., Kwok, C. K. & Wang, H., 23 Jul 2024, In: Analytical Chemistry. 96, 29, p. 11951-11958Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
5 Citations (Scopus) -
L-Rna Aptamers, Recombinant Polynucleotides, And Uses Thereof In Treating Alzheimer’S Disease
KWOK, C. K. (Inventor), 5 Aug 2024, (Accepted/In press/Filed) Priority No. 18/795,168Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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L-RNA 適體、重組多核苷酸及其於治療阿茲海默症的用途
KWOK, C. K. (Inventor), 5 Sept 2024, (Accepted/In press/Filed) Priority No. 202411244236.XResearch output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Rational Design of L-RNA Aptamer-Peptide Conjugate for Efficient Cell Uptake and G-quadruplex-Mediated Gene Control
Zhang, K., Nie, Q., Chi-Kong Lau, T. & Kit Kwok, C., 26 Feb 2024, In: Angewandte Chemie - International Edition. 63, 9, e202310798.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
3 Citations (Scopus) -
Selective recognition of RNA G-quadruplex in vitro and in cells by L-aptamer–D-oligonucleotide conjugate
Zhao, H., Lau, H. L., Zhang, K. & Kwok, C. K., 11 Dec 2024, In: Nucleic acids research. 52, 22, p. 13544-13560Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile2 Citations (Scopus)15 Downloads (CityUHK Scholars) -
Specific Targeting and Imaging of RNA G-Quadruplex (rG4) Structure Using Non-G4-Containing l-RNA Aptamer and Fluorogenic l-Aptamer
Lau, H. L., Zhao, H., Feng, H. & Kwok, C. K., 3 Sept 2024, (Online published) In: Small Methods. 2401097.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open Access1 Citation (Scopus) -
一種dU5`銜接子及其應用和構建的cDNA文庫
KWOK, C. K. (Inventor), YEUNG, P. Y. (Inventor) & ZHAO, J. (Inventor), 12 Apr 2024, Patent No. ZL202110037475.8, Priority No. 202110037475.8Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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共軛物及其用途
Translated title of the contribution :Conjugates, And Uses Thereof Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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2023
A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression
Lyu, K. & Kwok, C. K., 7 Jul 2023, In: Chemical Communications. 59, 53, p. 8230-8233Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile4 Citations (Scopus)22 Downloads (CityUHK Scholars) -
Aptamers as Functional Modules for DNA Nanostructures
Shiu, S.C.-C., Kinghorn, A. B., Guo, W., Slaughter, L. S., Ji, D., Mo, X., Wang, L., Tran, N. C., Kwok, C. K., Shum, A. H. C., Tse, E. C. M. & Tanner, J. A., 2023, DNA and RNA Origami: Methods and Protocols. Valero, J. (ed.). New York, NY: Humana Press, p. 301-337 (Methods in Molecular Biology; vol. 2639).Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review
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Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
Zhang, Y., Juhas, M. & Kwok, C. K., Apr 2023, In: Trends in Biotechnology. 41, 4, p. 528-544Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile52 Citations (Scopus)48 Downloads (CityUHK Scholars) -
Modified nucleic acid aptamers: development, characterization, and biological applications
Ji, D. (Co-first Author), Feng, H. (Co-first Author), Liew, S. W. (Co-first Author) & Kwok, C. K., Nov 2023, In: Trends in Biotechnology. 41, 11, p. 1360-1384 25 p.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile37 Citations (Scopus)48 Downloads (CityUHK Scholars) -
Peptides Selected by G4-mRNA Display-Seq Enable RNA G-Quadruplex Recognition and Gene Regulation
Mou, X. & Kwok, C. K., 30 Aug 2023, In: Journal of the American Chemical Society. 145, 34, p. 18693–18697Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
9 Citations (Scopus) -
RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays
Lyu, K. & Kwok, C. K., 2023, In: Methods in Enzymology. 691, p. 63-80 18 p.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
1 Citation (Scopus) -
Rna G-Quadruplex Based Proteolysis-Targeting Chimeras
KWOK, C. K. (Inventor) & ZHANG, K. (Inventor), 29 Nov 2023, (Accepted/In press/Filed) Priority No. 63/604,171Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Selective targeting of parallel G-quadruplex structure using L-RNA aptamer
Ji, D., Yuan, J.-H., Chen, S.-B., Tan, J.-H. & Kwok, C. K., 27 Nov 2023, In: Nucleic acids research. 51, 21, p. 11439-11452Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile16 Citations (Scopus)35 Downloads (CityUHK Scholars) -
Tuning Material States and Functionalities of G-Quadruplex-Modulated RNA-Peptide Condensates
Guo, W. (Co-first Author), Ji, D. (Co-first Author), Kinghorn, A. B., Chen, F., Pan, Y., Li, X., Li, Q., Huck, W. T. S., Kwok, C. K. & Shum, H. C., 1 Feb 2023, In: Journal of the American Chemical Society. 145, 4, p. 2375–2385Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile13 Citations (Scopus)45 Downloads (CityUHK Scholars) -
2022
Alternative splicing modulation by G-quadruplexes
Georgakopoulos-Soares, I., Parada, G. E., Wong, H. Y., Medhi, R., Furlan, G., Munita, R., Miska, E. A., Kwok, C. K. & Hemberg, M., 2022, In: Nature Communications. 13, 2404.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile55 Citations (Scopus)47 Downloads (CityUHK Scholars) -
An RNA G-Quadruplex Structure within the ADAR 5’UTR Interacts with DHX36 Helicase to Regulate Translation
Lyu, K., Chen, S.-B., Chow, E.Y.-C., Zhao, H., Yuan, J.-H., Cai, M., Shi, J., Chan, T.-F., Tan, J.-H. & Kwok, C. K., 23 Dec 2022, In: Angewandte Chemie (International Edition). 61, 52, e202203553.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile21 Citations (Scopus)41 Downloads (CityUHK Scholars) -
An ultra low-input method for global RNA structure probing uncovers Regnase-1-mediated regulation in macrophages
Piao, M. (Co-first Author), Li, P. (Co-first Author), Zeng, X. (Co-first Author), Wang, X.-W. (Co-first Author), Kang, L., Zhang, J., Wei, Y., Zhang, S., Tang, L., Zhu, J., Kwok, C. K., Hu, X. & Zhang, Q. C., Jan 2022, In: Fundamental Research. 2, 1, p. 2-13Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile6 Citations (Scopus)150 Downloads (CityUHK Scholars) -
Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application
Lam, S. Y., Lau, H. L. & Kwok, C. K., Dec 2022, In: Biosensors. 12, 12, 1142.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile33 Citations (Scopus)73 Downloads (CityUHK Scholars) -
Development of RNA G-quadruplex (rG4)-targeting l-RNA aptamers by rG4-SELEX
Umar, M. I., Chan, C.-Y. & Kwok, C. K., 20 Apr 2022, (Online published) In: Nature Protocols.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
16 Citations (Scopus) -
Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0
Zhao, J. (Co-first Author), Chow, E.Y.-C. (Co-first Author), Yeung, P. Y., Zhang, Q. C., Chan, T.-F. & Kwok, C. K., 2022, In: BMC Biology. 20, 257.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile11 Citations (Scopus)40 Downloads (CityUHK Scholars) -
High-throughput characterization of the role of non-B DNA motifs on promoter function
Georgakopoulos-Soares, I., Victorino, J., Parada, G. E., Agarwal, V., Zhao, J., Wong, H. Y., Umar, M. I., Elor, O., Muhwezi, A., An, J.-Y., Sanders, S. J., Kwok, C. K., Inoue, F., Hemberg, M. & Ahituv, N., 13 Apr 2022, In: Cell Genomics. 2, 4, 100111.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile31 Citations (Scopus)31 Downloads (CityUHK Scholars) -
Identification and targeting of G-quadruplex structures in MALAT1 long non-coding RNA
Mou, X., Liew, S. W. & Kwok, C. K., 11 Jan 2022, In: Nucleic Acids Research. 50, 1, p. 397-410Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile23 Citations (Scopus)165 Downloads (CityUHK Scholars) -
Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5' UTR rG4 unwinding and Anp32e translation
Chen, X., Xue, G., Zhao, J., Zhang, Y., Zhang, S., Wang, W., Li, Y., Yuan, J., He, L., Chan, C. Y., Liu, Y., Chen, W., Zhao, Y., Hu, P., Sun, H., Kwok, C. K. & Wang, H., 7 Jun 2022, In: Cell Reports. 39, 10, 110907.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile17 Citations (Scopus)55 Downloads (CityUHK Scholars) -
L-Rna Aptamers And Methods Of Identifying The Same
KWOK, C. K. (Inventor) & JI, D. (Inventor), 4 Nov 2022, (Accepted/In press/Filed) Priority No. 18/052,811Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Method of Producing An Aptamer And Uses Thereof
KWOK, C. K. (Inventor) & CHAN, C. Y. (Inventor), 10 May 2022, Patent No. US11,326,169, Priority No. 16/706,978Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
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Novel L-RNA Aptamer Controls APP Gene Expression in Cells by Targeting RNA G-Quadruplex Structure
Zhao, H., Wong, H. Y., Ji, D., Lyu, K. & Kwok, C. K., 13 Jul 2022, In: ACS Applied Materials & Interfaces. 14, 27, p. 30582-30594Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
14 Citations (Scopus) -
Recent advances in RNA structurome
Xu, B., Zhu, Y., Cao, C., Chen, H., Jin, Q., Li, G., Ma, J., Yang, S. L., Zhao, J., Zhu, J., Ding, Y., Fang, X., Jin, Y., Kwok, C. K., Ren, A., Wan, Y., Wang, Z., Xue, Y., Zhang, H. & Zhang, Q. C. & 1 others, , Jul 2022, In: Science China Life Sciences. 65, 7, p. 1285–1324Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open Access34 Citations (Scopus) -
RNA G-quadruplex structure contributes to cold adaptation in plants
Yang, X., Yu, H., Duncan, S., Zhang, Y., Cheema, J., Liu, H., Benjamin Miller, J., Zhang, J., Kwok, C. K., Zhang, H. & Ding, Y., 2022, In: Nature Communications. 13, 6224.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile34 Citations (Scopus)30 Downloads (CityUHK Scholars) -
Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
Feng, H. & Kwok, C. K., 1 Apr 2022, In: RSC Chemical Biology. 3, 4, p. 431-435Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile4 Citations (Scopus)41 Downloads (CityUHK Scholars) -
The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome
Dumetz, F., Enright, A. J., Zhao, J., Kwok, C. K. & Merrick, C. J., 2022, In: PLOS ONE. 17, 9, e0270863.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile1 Citation (Scopus)45 Downloads (CityUHK Scholars) -
2021
Bringing distant DNA together
Zhao, H. & Kwok, C. K., Feb 2021, In: Nature Chemical Biology. 17, 2, p. 125-126Research output: Journal Publications and Reviews › Comment/debate
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Circular L-RNA aptamer promotes target recognition and controls gene activity
Ji, D., Lyu, K., Zhao, H. & Kwok, C. K., 21 Jul 2021, In: Nucleic Acids Research. 49, 13, p. 7280-7291Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile33 Citations (Scopus)63 Downloads (CityUHK Scholars) -
Discovery of G-quadruplex-forming sequences in SARS-CoV-2
Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y., Mar 2021, In: Briefings in Bioinformatics. 22, 2, p. 1150-1160 11 p.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open Access84 Citations (Scopus) -
G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum
Dumetz, F., Chow, E.Y.-C., Harris, L. M., Liew, S. W., Jensen, A., Umar, M. I., Chung, B., Chan, T. F., Merrick, C. J. & Kwok, C. K., 2 Dec 2021, In: Nucleic Acids Research. 49, 21, p. 12486-12501Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile15 Citations (Scopus)64 Downloads (CityUHK Scholars) -
L-Rna Aptamer
KWOK, C. K. (Inventor) & JI, D. (Inventor), 21 Apr 2021, (Accepted/In press/Filed) Priority No. 17/236,600Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)