Prof. KWOK Chun Kit (郭駿傑)
Research Output
- 2025
- Accepted/In press/Filed
Rapid and sensitive one-pot CRISPR/Cas12a-based detection of enteroaggregative Escherichia coli
LIM, C. K. (Inventor), LIEW, S. W. (Inventor), KWOK, C. K. (Inventor) & LEE, P. K. H. (Inventor), 14 Feb 2025, (Accepted/In press/Filed) Priority No. 63/758,868Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Published
RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells
Zhang, K. (Co-first Author), Nie, Q. (Co-first Author), Li, M. (Co-first Author), Chen, X., Zhong, L., Dai, T. & Guo, X. & 5 others, , 10 Feb 2025, In: Nucleic Acids Research. 53, 3, gkaf039.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
- Published
Pre-Defined Stem-Loop Structure Library for the Discovery of L-RNA Aptamers that Target RNA G-Quadruplexes
Ji, D., Wang, B., Lo, K. W., Tsang, C. M. & Kwok, C. K., 27 Jan 2025, In: Angewandte Chemie International Edition. 64, 5, e202417247.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
- 2024
- Published
Selective recognition of RNA G-quadruplex in vitro and in cells by L-aptamer–D-oligonucleotide conjugate
Zhao, H., Lau, H. L., Zhang, K. & Kwok, C. K., 11 Dec 2024, In: Nucleic acids research. 52, 22, p. 13544-13560Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Scopus citations: 1 - Published
A selective HIV-1 RNA G-quadruplex-targeting L-aptamer–D-antisense conjugate inhibits HIV-1 minus strand transfer
Feng, H. & Kwok, C. K., 28 Nov 2024, In: Chemical Communications. 60, 92, p. 13558-13561Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Scopus citations: 1 - Accepted/In press/Filed
Conjugates, And Uses Thereof
KWOK, C. K. (Inventor) & ZHANG, K. (Inventor), 28 Nov 2024, (Accepted/In press/Filed) Priority No. 18/963,702Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Accepted/In press/Filed
共軛物及其用途
KWOK, C. K. (Inventor) & ZHANG, K. (Inventor), 28 Nov 2024, (Accepted/In press/Filed) Priority No. 202411727263.2Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Published
DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1
Zhang, Y., Zhao, J., Chen, X., Qiao, Y., Kang, J., Guo, X. & Yang, F. & 6 others, , 15 Nov 2024, In: Nature Communications. 15, 19 p., 9890.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
- Published
Capture of RNA G-quadruplex structures using an L-RNA aptamer
Lam, S. Y., Umar, M. I., Zhao, H., Zhao, J. & Kwok, C. K., 1 Oct 2024, In: RSC Chemical Biology. 5, 10, p. 1045-1051Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Scopus citations: 1 - Accepted/In press/Filed
L-RNA 適體、重組多核苷酸及其於治療阿茲海默症的用途
KWOK, C. K. (Inventor), 5 Sept 2024, (Accepted/In press/Filed) Priority No. 202411244236.XResearch output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Online published
Specific Targeting and Imaging of RNA G-Quadruplex (rG4) Structure Using Non-G4-Containing l-RNA Aptamer and Fluorogenic l-Aptamer
Lau, H. L., Zhao, H., Feng, H. & Kwok, C. K., 3 Sept 2024, (Online published) In: Small Methods. 2401097.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Scopus citations: 2 - Accepted/In press/Filed
L-Rna Aptamers, Recombinant Polynucleotides, And Uses Thereof In Treating Alzheimer’S Disease
KWOK, C. K. (Inventor), 5 Aug 2024, (Accepted/In press/Filed) Priority No. 18/795,168Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Published
Hook-Like DNAzyme-Activated Autocatalytic Biosensor for the Universal Detection of Pathogenic Bacteria
Liu, Y., Shi, Y., Wang, S., Liu, S., Shang, M., Zhao, B. & Liu, H. & 4 others, , 23 Jul 2024, In: Analytical Chemistry. 96, 29, p. 11951-11958Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Scopus citations: 4 - Accepted/In press/Filed
Stem-loop Structured Library for G4-SELEX-Seq: Design, Methods, and Applications
KWOK, C. K. (Inventor) & JI, D. (Inventor), 12 Jun 2024, (Accepted/In press/Filed) Priority No. 63/659,318Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Accepted/In press/Filed
An L-aptamer-ASO conjugate can specifically recognize a particular RNA G-quadruplex region and modulate gene activity
KWOK, C. K. (Inventor) & ZHAO, H. (Inventor), 20 May 2024, (Accepted/In press/Filed) Priority No. 63/649,850Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Published
一種dU5`銜接子及其應用和構建的cDNA文庫
KWOK, C. K. (Inventor), YEUNG, P. Y. (Inventor) & ZHAO, J. (Inventor), 12 Apr 2024, Patent No. ZL202110037475.8, Priority No. 202110037475.8Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Accepted/In press/Filed
Aptamer-Peptide Conjugates
KWOK, C. K. (Inventor) & ZHANG, K. (Inventor), 1 Mar 2024, (Accepted/In press/Filed) Priority No. 18/593,510Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- Published
Rational Design of L-RNA Aptamer-Peptide Conjugate for Efficient Cell Uptake and G-quadruplex-Mediated Gene Control
Zhang, K., Nie, Q., Chi-Kong Lau, T. & Kit Kwok, C., 26 Feb 2024, In: Angewandte Chemie - International Edition. 63, 9, e202310798.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Scopus citations: 2 - Accepted/In press/Filed
G4-Specific Peptides And Methods Of Identifying The Same
KWOK, C. K. (Inventor) & MOU, X. (Inventor), 30 Jan 2024, (Accepted/In press/Filed) Priority No. 18/427,626Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
- 2023
- Accepted/In press/Filed
Rna G-Quadruplex Based Proteolysis-Targeting Chimeras
KWOK, C. K. (Inventor) & ZHANG, K. (Inventor), 29 Nov 2023, (Accepted/In press/Filed) Priority No. 63/604,171Research output: Patents, Agreements and Assignments › RGC 51 - Patents (CityUHK)
