Biotechnology & Health Centre

2025

Characterization of extracellular vesicles released from Prochlorococcus MED4 at the steady state and under a light-dark cycle

Peng, Z. (Co-first Author), Liu, Y. (Co-first Author), Ma, H. (Co-first Author), Xiao, S., Au-Yeung, A., Zhang, L., Zeng, Q. & Guo, Y., 23 Jan 2025, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 380, 1918, 20230339.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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1 Citation (Scopus)

19 Downloads (CityUHK Scholars)

Dimethyl fumarate abrogates hepatocellular carcinoma growth by inhibiting Nrf2/Bcl-xL axis and enhances sorafenib’s efficacy

Faleti, O. D. (Co-first Author), Alsaadawe, M. (Co-first Author), Long, J. (Co-first Author), Luo, Q. (Co-first Author), Hu, L., Zhang, Y., Deng, S., Wu, G., Fang, W., He, M. & Lyu, X., 2025, In: Scientific Reports. 15, 16724.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Harnessing intracellular bacteria in bladder by intravesical delivery of antibiotics-loaded nanodiamonds to reduce the recurrence of urinary tract infection

Law, C. O. K. (Co-first Author), Leung, H. M. (Co-first Author), Wang, M. (Co-first Author), Nie, Q., Pham, Q. H., Han, K. C., Wong, T. S., Chow, K. T., Lo, P. K. & Lau, T. C. K., 2025, In: Journal of Nanobiotechnology. 23, 367.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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5 Downloads (CityUHK Scholars)

Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages

Leung, H. M. (Co-first Author), Chan, H. Y. (Co-first Author), Klimezak, M., Liu, L. S., Karam, P., Specht, A., Bolze, F. & Lo, P. K., 12 May 2025, In: Biomacromolecules. 26, 5, p. 3113-3127

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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1 Citation (Scopus)

10 Downloads (CityUHK Scholars)

2024

A dual-functional photosensitizer for mitochondria-targeting photodynamic therapy and synchronous polarity monitoring

Yang, L., Gan, S., Zhang, J., Jiang, Y., Chen, Q. & Sun, H., 21 Nov 2024, In: Journal of Materials Chemistry B. 12, 43, p. 11259-11264

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

2 Citations (Scopus)

An integrated and multi-functional droplet-based microfluidic platform for digital DNA amplification

Wang, Y., Zhou, X., Yang, Z., Xu, T., Fu, H., Fong, C.-C., Sun, J., Chin, Y. R., Zhang, L., Guan, X. & Yang, M., 15 Feb 2024, In: Biosensors and Bioelectronics. 246, 115831.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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4 Citations (Scopus)

62 Downloads (CityUHK Scholars)

Cellulose Nanofibrils of High Immunoaffinity for Efficient Enrichment of Small Extracellular Vesicles

Wang, Z., Dai, J., He, H., Si, T., Ng, K., Zheng, S., Zhou, X., Zhou, Z., Yuan, H. & Yang, M., 20 Nov 2024, In: Small Methods. 8, 11, 2400426.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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2 Citations (Scopus)

14 Downloads (CityUHK Scholars)

Circulating Tumor Cells Culture: Methods, Challenges, and Clinical Applications

Zhou, Z., Cai, S., Zhou, X., Zhao, W., Sun, J., Zhou, Z., Yang, Z., Li, W., Wang, Z., Zou, H., Fu, H., Wang, X., Khoo, B. L. & Yang, M., 27 Dec 2024, (Online published) In: Small Methods. 2401026.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

DNA polymerase delta governs parental histone transfer to DNA replication lagging strand

Tian, C. (Co-first Author), Zhang, Q. (Co-first Author), Jia, J. (Co-first Author), Zhou, J. (Co-first Author), Zhang, Z. (Co-first Author), Karri, S., Jiang, J., Dickinson, Q., Yao, Y., Tang, X., Huang, Y., Guo, T., He, Z., Liu, Z., Gao, Y., Yang, X., Wu, Y., Chan, K. M., Zhang, D. & Han, J. & 2 others, Yu, C. & Gan, H., 14 May 2024, In: Proceedings of the National Academy of Sciences. 121, 20, e2400610121.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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10 Citations (Scopus)

27 Downloads (CityUHK Scholars)

Enzyme-Directed and Organelle-Specific Sphere-to-Fiber Nanotransformation Enhances Photodynamic Therapy in Cancer Cells

Gan, S., Yang, L., Heng, Y., Chen, Q., Wang, D., Zhang, J., Wei, W., Liu, Z., Njoku, D. I., Chen, J. L., Hu, Y. & Sun, H., 20 Nov 2024, In: Small Methods. 8, 11, 2301551.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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6 Citations (Scopus)

Quantitative comparison of the renal pelvic urine and bladder urine to examine modifications of the urine proteome by the lower urinary tract

Pan, Y., Wong, C.Y.-P., Ma, H., Tse, R.T.-H., Cheng, C.K.-L., Tan, M., Chiu, P.K.-F., Teoh, J.Y.-C., Wang, X., Ng, C.-F. & ZHANG, L., Mar 2024, In: Proteomics - Clinical Applications. 18, 2, 2300004.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Strong and high-conductivity hydrogels with all-polymer nanofibrous networks for applications as high-capacitance flexible electrodes

He, H., Chen, Y., Pu, A., Wang, L., Li, W., Zhou, X., Tang, C. Y., Ban, K., Yang, M. & Xu, L., 2024, In: npj Flexible Electronics. 8, 56.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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7 Citations (Scopus)

23 Downloads (CityUHK Scholars)

Ultra-stable threose nucleic acid-based biosensors for rapid and sensitive nucleic acid detection and in vivo imaging

Li, P., Zhu, C., Liu, L. S., Chang, T. J. H., Chu, H. C., Li, Z., Mao, Z., Wang, F. & Lo, P. K., 15 Mar 2024, In: Acta Biomaterialia. 177, p. 472-485

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

2023

ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression

Zhang, S., Yang, F., Huang, Y., He, L., Li, Y., Wan, Y. C. E., Ding, Y., Chan, K. M., Xie, T., Sun, H. & Wang, H., 2023, In: Nature Communications. 14, 4978.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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16 Citations (Scopus)

48 Downloads (CityUHK Scholars)

Author Correction: ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression

Zhang, S., Yang, F., Huang, Y., He, L., Li, Y., Wan, Y. C. E., Ding, Y., Chan, K. M., Xie, T., Sun, H. & Wang, H., 2023, In: Nature Communications. 14, 5968.

Research output: Journal Publications and Reviews › Erratum

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1 Citation (Scopus)

17 Downloads (CityUHK Scholars)

Comparative analysis of outer membrane vesicles from uropathogenic Escherichia coli reveal the role of aromatic amino acids synthesis proteins in motility

Liu, L. (Co-first Author), Law, C. O. K. (Co-first Author), Nie, Q. (Co-first Author), Pham, H. Q., Ma, H., Zhang, L., Ho, P. L. & Lau, T.C.-K., Jan 2023, In: International Journal of Medical Microbiology. 313, 1, 151573.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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2 Citations (Scopus)

91 Downloads (CityUHK Scholars)

Mutation-independent gene knock-in therapy targeting 5'UTR for autosomal dominant retinitis pigmentosa

Hoang, D. A., Liao, B., Zheng, Z. & Xiong, W., 2023, In: Signal Transduction and Targeted Therapy. 8, 100.

Research output: Journal Publications and Reviews › Letter

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5 Citations (Scopus)

35 Downloads (CityUHK Scholars)

Nanometre-Scale Biosensors Revolutionizing Applications in Biomedical and Environmental Research

Lo, P. K., Nov 2023, In: Biosensors. 13, 11, 969.

Research output: Journal Publications and Reviews › Editorial Preface

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2 Citations (Scopus)

31 Downloads (CityUHK Scholars)

Polyphenol-Based Assembly Nanosystems as Multifunctional Biopharmaceutical Platform

Jiang, X., Zhang, J., Lo, P. K. & Mao, Z., Jun 2023, In: Advanced NanoBiomed Research. 3, 6, 2200168.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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11 Citations (Scopus)

41 Downloads (CityUHK Scholars)

Rational Design of Self-Reporting Photosensitizers for Cell Membrane-Targeted Photodynamic Therapy

Yang, L., Chen, Q., Gan, S., Huang, C., Zhang, H. & Sun, H., 15 Aug 2023, In: Analytical Chemistry. 95, 32, p. 11988–11996

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

12 Citations (Scopus)

Small-molecule fluorescent probes for plasma membrane staining: Design, mechanisms and biological applications

Yang, L., Chen, Q., Wang, Z., Zhang, H. & Sun, H., 1 Jan 2023, In: Coordination Chemistry Reviews. 474, 214862.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

40 Citations (Scopus)

Super-enhancer-driven cancer stemness and metastasis genes in triple-negative breast cancer

Hu, J., He, Q., Huang, H., Wang, X. & Chin, R., May 2023.

Research output: Conference Papers › Abstract › peer-review

Universal Strategy to Develop Fluorogenic Probes for Lysine Deacylase/Demethylase Activity and Application in Discriminating Demethylation States

Wei, W. (Co-first Author), Zhang, J. (Co-first Author), Xu, Z., Liu, Z., Huang, C., Cheng, K., Meng, L., Matsuda, Y., Hao, Q., Zhang, H. & Sun, H., 27 Jan 2023, In: ACS Sensors. 8, 1, p. 28-39

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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2 Citations (Scopus)

55 Downloads (CityUHK Scholars)

Versatile nanodiamond-based tools for therapeutics and bioimaging

Leung, H. M., Chu, H. C., Mao, Z.-W. & Lo, P. K., 21 Feb 2023, In: Chemical Communications. 59, 15, p. 2039-2055

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

19 Citations (Scopus)

2022

A dual-function chemical probe for detecting erasers of lysine lipoylation

Xie, Y., Zhang, J., Yang, L., Chen, Q., Hao, Q., Zhang, L. & Sun, H., Jan 2022, In: Frontiers of Chemical Science and Engineering. 16, 1, p. 121–127

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

Advances in Approaches to Study Chromatin-Mediated Epigenetic Memory

Yao, Y., Wen, Q., Zhang, T., Yu, C., Chan, K. M. & Gan, H., 21 Jan 2022, In: ACS Synthetic Biology. 11, 1, p. 16–25

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

A megadiverse naïve library derived from numerous camelids for efficient and rapid development of VHH antibodies

Wang, M., Wei, L., Xiang, H., Ren, B., Liu, X., Jiang, L., Yang, N. & Shi, J., 15 Nov 2022, In: Analytical Biochemistry. 657, 114871.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging

Yang, L., Chen, Q., Wan, Y., Gan, S., Li, S., Lee, C.-S., Jiang, Y., Zhang, H. & Sun, H., 28 Aug 2022, In: Chemical Communications. 58, 67, p. 9425-9428

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

15 Citations (Scopus)

Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC

Song, Z., Lian, S., Mak, S., Chow, M.Z.-Y., Xu, C., Wang, W., Keung, H. Y., Lu, C., Kebede, F. T., Gao, Y., Cheuk, W., Cho, W. C. S., Yang, M. & Zheng, Z., Feb 2022, In: Journal of Thoracic Oncology. 17, 2, p. 264-276 13 p.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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20 Citations (Scopus)

72 Downloads (CityUHK Scholars)

Defining Proximity Proteome of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling

Li, X., Zhou, J., Zhao, W., Wen, Q., Wang, W., Peng, H., Gao, Y., Bouchonville, K. J., Offer, S. M., Chan, K., Wang, Z., Li, N. & Gan, H., Feb 2022, In: Genomics, Proteomics and Bioinformatics. 20, 1, p. 87–100

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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11 Citations (Scopus)

105 Downloads (CityUHK Scholars)

Dually stimulative single-chain polymeric nano lock with dynamic ligands for sensitive detection of circulating tumor cells

Cui, M., Xiaoyu Chen, Luo, X., Zhou, Z., Chen, Z., Zhou, Z., Zhou, X., Zou, H., Xu, T., Wang, S. & Yang, M., 1 Dec 2022, In: Biosensors and Bioelectronics. 217, 114692.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

Electrophilic Sulfonium-Promoted Peptide and Protein Amidation in Aqueous Media

Wan, C., Feng, Y., Hou, Z., Lian, C., Zhang, L., An, Y., Sun, J., Yang, D., Jiang, C., Yin, F., Wang, R. & Li, Z., 21 Jan 2022, In: Organic Letters. 24, 2, p. 581–586

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

20 Citations (Scopus)

FGFR2–BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model

Lei, J. H., Zhang, L., Wang, Z., Peltier, R., Xie, Y., Chen, G., Lin, S., Miao, K., Deng, C.-X. & Sun, H., Apr 2022, In: Frontiers in Immunology. 13, 861221.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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1 Citation (Scopus)

42 Downloads (CityUHK Scholars)

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination

Yuen, C. T. L., Thean, D. G. L., Chan, B. K. C., Zhou, P., Kwok, C. C. S., Chu, H. Y., Cheung, M. S. H., Wang, B., Chan, Y. M., Mak, S. Y. L., Leung, A. Y., Choi, G. C. G., Zheng, Z. & Wong, A. S. L., 22 Feb 2022, In: Nucleic Acids Research. 50, 3, p. 1650-1660

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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17 Citations (Scopus)

42 Downloads (CityUHK Scholars)

Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells

Wang, R., Yang, D., Tian, T., An, Y., Wan, C., Chang, Q., Liang, M., Hou, Z., Wang, Y., Zhang, L. & Li, Z., 15 Mar 2022, In: Analytical Chemistry. 94, 10, p. 4366-4372

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

18 Citations (Scopus)

Lrwd1 impacts cell proliferation and the silencing of repetitive DNA elements

Kang, T. Z. E., Wan, Y. C. E., Zhang, Z. & Chan, K. M., May 2022, In: Genesis. 60, 4-5, e23475.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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3 Citations (Scopus)

46 Downloads (CityUHK Scholars)

Nucleic Acids and Their Analogues for Biomedical Applications

Wang, F., Li, P., Chu, H. C. & Lo, P. K., Feb 2022, In: Biosensors. 12, 2, 93.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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51 Citations (Scopus)

70 Downloads (CityUHK Scholars)

Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB

Li, Y., Xu, W., Ren, Y., Cheung, H.-C., Huang, P., Kaur, G., Kuo, C.-J., McDonough, S. P., Fubini, S. L., Lipkin, S. M., Deng, X., Chang, Y.-F. & Huang, L., Oct 2022, In: mBio. 13, 5, 18 p.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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5 Citations (Scopus)

37 Downloads (CityUHK Scholars)

Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2

Mai, S., Zhu, X., Wan, E. Y. C., Wu, S., Yonathan, J. N., Wang, J., Li, Y., Ma, J. Y. W., Zuo, B., Tse, D.Y.-Y., Lo, P.-C., Wang, X., Chan, K. M., Wu, D. M. & Xiong, W., Jul 2022, In: Development. 149, 14, dev200633.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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7 Citations (Scopus)

82 Downloads (CityUHK Scholars)

Reaction-based fluorescent and chemiluminescent probes for formaldehyde detection and imaging

Huang, S., Li, Z., Liu, M., Zhou, M., Weng, J., He, Y., Jiang, Y., Zhang, H. & Sun, H., 4 Feb 2022, In: Chemical Communications. 58, 10, p. 1442-1453

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

33 Citations (Scopus)

Self-assembled nano-photosensitizer for targeted, activatable, and biosafe cancer phototheranostics

Cheng, K. (Co-first Author), Qi, J. (Co-first Author), Zhang, J. (Co-first Author), Li, H., Ren, X., Wei, W., Meng, L., Li, J., Li, Q., Zhang, H., Deng, W., Sun, H. & Mei, L., Dec 2022, In: Biomaterials. 291, 121916.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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23 Citations (Scopus)

18 Downloads (CityUHK Scholars)

Systematic Screening of Trigger Moieties for Designing Formaldehyde Fluorescent Probes and Application in Live Cell Imaging

Jiang, Y., Huang, S., Liu, M., Li, Z., Xiao, W., Zhang, H., Yang, L. & Sun, H., Oct 2022, In: Biosensors. 12, 10, 855.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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2 Citations (Scopus)

46 Downloads (CityUHK Scholars)

Upregulation of Receptor Tyrosine Kinase Activity and Stemness as Resistance Mechanisms to Akt Inhibitors in Breast Cancer

Tsang, T., He, Q., Cohen, E. B., Stottrup, C., Lien, E. C., Zhang, H., Lau, C. G. & Chin, Y. R., Oct 2022, In: Cancers. 14, 20, 5006.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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4 Citations (Scopus)

48 Downloads (CityUHK Scholars)

2021

An activatable AIEgen probe for in-situ monitoring and long-term tracking of ferrous ions in living cells

Yang, L., Chen, Q., Gan, S., Guo, Q., Zhang, J., Zhang, H., Xie, Y., Xiao, H., Wang, W. & Sun, H., Jun 2021, In: Dyes and Pigments. 190, 109271.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

17 Citations (Scopus)

ANLN Enhances Triple-Negative Breast Cancer Stemness Through TWIST1 and BMP2 and Promotes its Spheroid Growth

Maryam, A. & Chin, Y. R., Jul 2021, In: Frontiers in Molecular Biosciences. 8, 700973.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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17 Citations (Scopus)

45 Downloads (CityUHK Scholars)

Author Correction: CRISPR-assisted detection of RNA–protein interactions in living cells

Yi, W., Li, J., Zhu, X., Wang, X., Fan, L., Sun, W., Liao, L., Zhang, J., Li, X., Ye, J., Chen, F., Taipale, J., Chan, K. M., Zhang, L. & Yan, J., Feb 2021, In: Nature Methods. 18, 2, p. 219

Research output: Journal Publications and Reviews › Erratum

Open Access