Uncovering the secret of RNA paves the way for drug discovery for Covid-19 - CityU Scholars

Description

A research team led by Dr Yan Jian, Dr Zhang Liang and Dr Chan Kui-ming in the Department of Biomedical Sciences (BMS) at City University of Hong Kong (CityU) has developed a new method for identifying binding proteins of non-coding RNAs in living cells.

The findings can be applied in cancer diagnosis and stem cell research, and may even help to identify potential antiviral drug targets to combat Covid-19. They were published in the latest issue of Nature Methods under the title “CRISPR-assisted detection of RNA-protein interactions in living cells”.

Period	10 Aug 2020

Media coverage

Title	Uncovering the secret of RNA paves the way for drug discovery for Covid-19
Description	Led by Dr Yan Jian, Dr Zhang Liang and Dr Chan Kui-ming, all of whom are Assistant Professors in the Department of Biomedical Sciences (BMS) at City University of Hong Kong (CityU), the research team has developed a new method called CRISPR-Assisted RNA-Protein Interaction Detection (CAPRID) for identifying binding proteins of any target RNA in living cells. The findings were published in the latest issue of Nature Methods under the title “CRISPR-assisted detection of RNA-protein interactions in living cells”. Dr Chan, Dr Yan and Dr Zhang are the corresponding authors of the paper. Some of the co-first authors of the paper are Li Jingyu and Zhu Xiaoxuan, PhD students from BMS.
Persons	Jian YAN Department of Biomedical Sciences Liang ZHANG Department of Biomedical Sciences Kui Ming CHAN Department of Biomedical Sciences Jingyu LI Department of Biomedical Sciences Xiaoxuan ZHU Department of Biomedical Sciences
Media name/outlet	CityU NewsCentre
Place	Hong Kong
Media type	Web
Producer/Author	Kenix Wong
Date	10/08/20
Link	https://www.cityu.edu.hk/media/news/2020/08/10/uncovering-secret-rna-paves-way-drug-discovery-covid-19