Breakthrough technology indicates earlier detection for Alzheimer’s disease

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Description

A research team co-led by a scientist at City University of Hong Kong (CityU) has discovered a new, non-invasive way to detect early-stage Alzheimer’s disease, helping patients get the necessary treatments around 10 years before any symptoms appear.

In collaboration with Johns Hopkins University in the US, Dr Kannie Chan Wai-yan, Associate Professor in the Department of Biomedical Engineering (BME) at CityU, and her research team have developed a molecular imaging approach based on Magnetic Resonance Imaging (MRI). The MRI approach dynamically measures changes in the levels of glucose in the brain’s lymphatic system, which could provide early clues about the disease.

The findings were published in the latest issue of the scientific journal Science Advances under the title “Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose enhanced MRI”.

Dr Kannie Chan Wai-yan and Dr Xu Jiadi from Johns Hopkins University School of Medicine are the corresponding authors of the paper. The first author of the paper is Huang Jianpan, PhD student from CityU’s BME. Other co-authors from CityU included Han Xiongqi and Joseph Lai Ho-chi, PhD students from BME.

Period14 May 2020 → 15 May 2020

Media coverage

Title城大研非侵入方法 識別早期阿茲海默症
Description城大生物醫學工程學系與美國約翰.霍普金斯大學,合作研究是次「動態葡萄糖增強磁力共振分子成像」(DGE-MRI)技術。阿茲海默症早期病徵不明顯,難及早識別,或有礙治療。城市大學以磁力共振成像(MRI)為基礎,研發出分子成像方法,透過注射天然葡萄糖,檢測腦淋巴系統中的葡萄糖水平變化,能及早識別病症;且有關技術屬非侵入式方法,可更安全地進行檢測,冀3年內可開展臨床試驗。是次研究成果已在最新一期科學期刊《科學進展》發表。
Persons
Media name/outlet晴報
PlaceHong Kong
Media typeWeb
Producer/Author胡靜嫻
Date15/05/20
Linkhttps://skypost.ulifestyle.com.hk/article/2643637/%E5%9F%8E%E5%A4%A7%E7%A0%94%E9%9D%9E%E4%BE%B5%E5%85%A5%E6%96%B9%E6%B3%95%20%E8%AD%98%E5%88%A5%E6%97%A9%E6%9C%9F%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%97%87
Title城大研非侵入式 早測無症狀腦退化
Description城大生物醫學工程學系副教授陳葦恩及其研究團隊,與美國約翰霍普金斯大學合作,以磁力共振成像(MRI)為基礎,開發出一種基於化學交換飽和轉移磁力共振成像(CEST MRI)的新方法,有助早期檢測阿茲海默症,讓患者在未出現任何症狀前約10年就能接受治療。
Persons
Media name/outletLion Rock Daly
PlaceHong Kong
Media typeWeb
Date15/05/20
Linkwww.lionrockdaily.com/2020/05/15/11.pdf
Title城大新成像法 早10年發現腦退化
Description香港城市大學生物醫學工程研究團隊,研發出新的磁力共振分子成像(MRI)方法,透過動態測量腦淋巴系統中葡萄糖水平的變化,聲稱可找出阿茲海默症(俗稱腦退化)潛在患者,讓他們在未出現任何症狀前大約10年,便開始接受治療。
Persons
Media name/outlet信報財經
PlaceHong Kong
Media typeWeb
Date15/05/20
Linkhttps://www1.hkej.com/dailynews/finnews/article/2466103/%E5%9F%8E%E5%A4%A7%E6%96%B0%E6%88%90%E5%83%8F%E6%B3%95+%E6%97%A910%E5%B9%B4%E7%99%BC%E7%8F%BE%E8%85%A6%E9%80%80%E5%8C%96
Title城大新技術 及早識別老人癡呆症
Description長者容易患阿茲海默症,即俗稱的「老人癡呆症」,香港城市大學科學家團隊研發出「動態葡萄糖增強磁力共振分子成象」技術,評估小鼠大腦淋巴系統的葡萄糖攝取及清除率,較以往侵入式、具放射性的檢查安全及便宜,更有助患者早期識別並接受藥物治療,減低神經元的受損程度。
Persons
Media name/outlet東方日報
PlaceHong Kong
Media typeWeb
Date15/05/20
Linkhttps://orientaldaily.on.cc/cnt/news/20200515/00176_038.html
Title城大研磁力共振成像法 測早期阿茲海默症
Description愈早發現患上阿茲海默症,愈早接受藥物治療,神經元的損失就愈少,但阿茲海默症在早期階段診斷困難,因其早期症狀與正常衰老的特徵相似。城大生物醫學工程學系副教授陳葦恩及其團隊研發出一種磁力共振分子成像方法,有助檢測早期阿茲海默症。
Persons
Media name/outlet大公報
PlaceHong Kong
Media typeWeb
Producer/Author練怡蘭
Date15/05/20
Linkwww.takungpao.com.hk/news/232109/2020/0515/448744.html
Title城大新成像法 早10年發現腦退化
Description香港城市大學生物醫學工程研究團隊,研發出新的磁力共振分子成像(MRI)方法,透過動態測量腦淋巴系統中葡萄糖水平的變化,聲稱可找出阿茲海默症(俗稱腦退化)潛在患者,讓他們在未出現任何症狀前大約10年,便開始接受治療。相關研究已在最新一期科學期刊《科學進展》上發表。
Persons
Media name/outletStartUpBeat
PlaceHong Kong
Media typeWeb
Date15/05/20
Linkstartupbeat.hkej.com/?p=87333
TitleGlucose-measuring Imaging Technique May Identify the Early Stages of Alzheimer's
DescriptionCollaborative research by City University of Hong Kong (CityU) and Johns Hopkins University has developed a new non-invasive molecular imaging approach based on magnetic resonance imaging (MRI) to dynamically measure glucose level changes in the brain's lymphatic system. Their discovery may help in identifying Alzheimer's disease at early stages so that treatments can start as soon as possible.
Persons
Media name/outletTECHNOLOGY NETWORKS
PlaceUnited Kingdom
Media typeWeb
Date15/05/20
Linkhttps://www.technologynetworks.com/tn/news/glucose-measuring-imaging-technique-may-identify-the-early-stages-of-alzheimers-334883
TitleBreakthrough technology indicates earlier detection for Alzheimer’s disease
DescriptionA molecular imaging approach based on Chemical Exchange Saturation Transfer Magnetic Resonance Imaging (CEST MRI) has been developed by Dr Kannie Chan Wai-yan, Associate Professor in the Department of Biomedical Engineering (BME) at CityU, and her research team in collaboration with Johns Hopkins University in the US. The MRI approach dynamically measures changes in the levels of glucose in the brain’s lymphatic system, which could provide early clues about the disease.

The new imaging method is compatible with MRI machines commonly-used in clinics and hospitals, which means a low set-up cost and an easier transfer to clinical applications. Dr Chan anticipates that clinical trials can be conducted in three years.
Persons
Media name/outletCityU NewsCentre
PlaceHong Kong
Media typeWeb
Producer/AuthorKenix Wong
Date14/05/20
Linkhttps://www.cityu.edu.hk/media/news/2020/05/14/breakthrough-technology-indicates-earlier-detection-alzheimers-disease
TitleNew MRI technique for early detection of Alzheimer's
DescriptionA research team co-led by a scientist at City University of Hong Kong (CityU) has discovered a new, non-invasive way to detect early-stage Alzheimer’s disease, helping patients get the necessary treatments around 10 years before any symptoms appear.
Persons
Media name/outlethealthcare-in-europe.com
PlaceGermany
Media typeWeb
Date14/05/20
Linkhttps://healthcare-in-europe.com/en/news/new-mri-technique-for-early-detection-of-alzheimer-s.html
TitleNew method to detect Alzheimer’s could identify disease 10 years before onset of symptoms, Hong Kong researchers say
DescriptionDr Kannie Chan Wai-yan, an associate professor at City University’s department of biomedical engineering who co-led the research team, used MRI scanning to trace glucose injected into the brains of mice. A slow absorption and processing rate of the sugar pointed to signs of Alzheimer's.
Persons
Media name/outletSouth China Morning Post
PlaceHong Kong
Media typeWeb
Producer/AuthorZoe Low
Date14/05/20
Linkhttps://www.scmp.com/news/hong-kong/health-environment/article/3084444/new-method-detect-alzheimers-could-identify
Title【城大研究】磁力共振睇腦部變化 識別早期阿茲海默症
Description城大生物醫學工程學系與美國約翰.霍普金斯大學合作研究是次「動態葡萄糖增強磁力共振分子成象」(DGEMRI)技術。城市大學以磁力共振成像(MRI)為基礎,研發出分子成像方法,透過注射天然葡萄糖檢測腦淋巴系統中葡萄糖水平的變化,識別早期阿茲海默症;且有關技術屬非侵入式方法,可更安全地進行檢測。這項研究成果已在最新一期科學期刊《科學進展》上發表。
Persons
Media name/outlet晴報
PlaceHong Kong
Media typeWeb
Producer/Author胡靜嫻
Date14/05/20
Linkhttps://skypost.ulifestyle.com.hk/article/2643275/【城大研究】磁力共振睇腦部變化%20識別早期阿茲海默症
Title城大研發非侵入式方法有助早期檢測阿茲海默症
Description城大生物醫學工程學系副教授陳葦恩及研究團隊,與美國約翰.霍普金斯大學合作,以磁力共振成像為基礎,研發出分子成像方法,透過動態測量腦淋巴系統中葡萄糖水平的變化,對阿茲海默症作早期診斷。
Persons
Media name/outlet香港電台
PlaceHong Kong
Media typeWeb
Date14/05/20
Linkhttps://news.rthk.hk/rthk/ch/component/k2/1526211-20200514.htm
Title城大新技術偵阿茲海默症 及早識別可減神經元受損
Description香港城市大學科學家團隊今(14日)研發出「動態葡萄糖增強磁力共振分子成象」(DGEMRI)技術,可無創地評估小鼠大腦淋巴系統的葡萄糖攝取及清除率,較以往侵入式、具放射性的檢查安全及便宜,更有助患者早期識別並接受藥物治療,減低神經元的受損程度。有關研究已發表在最新一期科學期刊《科學進展》。
Persons
Media name/outlet東網
PlaceHong Kong
Media typeWeb
Date14/05/20
Linkhttps://hk.on.cc/hk/bkn/cnt/news/20200514/bkn-20200514170634059-0514_00822_001.html